Fig. 4
From: The role of Sphingomyelin synthase 2 (SMS2) in platelet activation and its clinical significance
PLCγ/PI3K/Akt phosphorylation mediated reduction effects of SMS2 deficiency on platelet activation. a SMS2 –/– diminished thrombin- and collagen-induced PLCγ/PI3K/Akt phosphorylation. Results shown are representative images of at least 3 experiments using WT and SMS2 –/– platelets. b D609 weakened PLCγ/PI3K/Akt phosphorylation in human platelets after stimulated by thrombin (0.03 U/mL) in a dose-dependent manner. Results shown are representative images of at least 3 experiments. c-f SMS2 expression in healthy people and patients with SAP, ACS and PH (Health = 27, SAP = 12, ACS = 12, PH = 15, n.s. P > 0.05, *** P < 0.001)