Table 2 The linear mixed-effects models show the difference in average fibrinogen, D-dimer, CRP, and ferritin concentration development over time in mechanically ventilated patients with and without clinical pulmonary thromboembolism
Model | Regression coefficient (95% CI) Fibrinogen (g/L) | p-value | Regression coefficient (95% CI) D-Dimer (μg/L) | p-value | Regression coefficient (95% CI) CRP (mg/L) | p-value | Regression coefficient (95% CI) Ferritin (μg/L) | p-value |
|---|---|---|---|---|---|---|---|---|
Model 1: Crude | ||||||||
 No clinical PTE (reference) | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. |
 Presence of clinical PTE a | 0.2 (− 0.8–1.2) | 0.672 | 2040 (− 4655–8735) | 0.541 | 28 (− 25–80) | 0.295 | − 714 (− 1666–238) | 0.138 |
Model 2: Model 1 additionally adjusted for sex, age, Apache -II score, BMI (continuous, kg/m2) and nadroparin dosing (dose in units), and unfractionated heparin usage (yes/no) | ||||||||
 No clinical PTE (reference) | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. |
 Presence of clinical PTE a | −0.9 (− 1.6 – − 0.1) | 0.030 | 561 (−6212–7334) | 0.868 | 27 (−32–86) | 0.359 | −1045 (− 1983 – − 106) | 0.031 |
Model 3 additionally adjusted for CRP and ferritin or fibrinogen and D-dimer | ||||||||
 No clinical PTE (reference) | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. | Ref. |
 Presence of clinical PTE a | −0.8 (−1.6–0) | 0.061 | 3304(− 1969–8577) | 0.214 | 19 (−37–75) | 0.494 | −592 (− 1426–242) | 0.161 |