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Table 2 The linear mixed-effects models show the difference in average fibrinogen, D-dimer, CRP, and ferritin concentration development over time in mechanically ventilated patients with and without clinical pulmonary thromboembolism

From: Serial markers of coagulation and inflammation and the occurrence of clinical pulmonary thromboembolism in mechanically ventilated patients with SARS-CoV-2 infection; the prospective Maastricht intensive care COVID cohort

Model Regression coefficient (95% CI)
Fibrinogen (g/L)
p-value Regression coefficient (95% CI)
D-Dimer (μg/L)
p-value Regression coefficient (95% CI)
CRP (mg/L)
p-value Regression coefficient (95% CI)
Ferritin (μg/L)
p-value
Model 1: Crude
 No clinical PTE (reference) Ref. Ref. Ref. Ref. Ref. Ref. Ref. Ref.
 Presence of clinical PTE a 0.2 (− 0.8–1.2) 0.672 2040 (− 4655–8735) 0.541 28 (− 25–80) 0.295 − 714 (− 1666–238) 0.138
Model 2: Model 1 additionally adjusted for sex, age, Apache -II score, BMI (continuous, kg/m2) and nadroparin dosing (dose in units), and unfractionated heparin usage (yes/no)
 No clinical PTE (reference) Ref. Ref. Ref. Ref. Ref. Ref. Ref. Ref.
 Presence of clinical PTE a −0.9 (− 1.6 – − 0.1) 0.030 561 (−6212–7334) 0.868 27 (−32–86) 0.359 −1045 (− 1983 – − 106) 0.031
Model 3 additionally adjusted for CRP and ferritin or fibrinogen and D-dimer
 No clinical PTE (reference) Ref. Ref. Ref. Ref. Ref. Ref. Ref. Ref.
 Presence of clinical PTE a −0.8 (−1.6–0) 0.061 3304(− 1969–8577) 0.214 19 (−37–75) 0.494 −592 (− 1426–242) 0.161
  1. PTE pulmonary thromboembolism; CI confidence interval; APACHE Acute Physiology and Chronic Health Evaluation; BMI body mass index
  2. aA negative regression coefficient indicates that the fibrinogen concentration is, on average, lower over time compared to the reference group