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Table 3 Stratified for men and women. The linear mixed-effects models show the average difference in fibrinogen, D-dimer, CRP, and ferritin concentration development over time in mechanically ventilated patients with and without clinical pulmonary thromboembolism

From: Serial markers of coagulation and inflammation and the occurrence of clinical pulmonary thromboembolism in mechanically ventilated patients with SARS-CoV-2 infection; the prospective Maastricht intensive care COVID cohort

Model Regression coefficient (95% CI)
Men (n = 33)
Fibrinogen (g/L)
p-value Regression coefficient (95% CI)
Women (n = 6)
Fibrinogen (g/L)
p-value
Model 1: Crude
 No clinical PTE (reference) Ref. Ref. Ref. Ref.
 Presence of clinical PTE * −0.05 (− 1.2–1.1) 0.926 0.425 (−1.4–2.3) 0.564
Model 2: Model 1 additionally adjusted for age, sex, Apache -II score, BMI (continuous, kg/m2) and nadroparin dosing (dose in units), and unfractionated heparin usage (yes/no)
 No clinical PTE (reference) Ref. Ref. Ref. Ref.
 Presence of clinical PTE a −1.3 (− 2.2 – − 0.4) 0.006 1.3 (− 11.6–14.2) 0.427
Model 3: Model 2 additionally adjusted for CRP and ferritin or fibrinogen and D-dimer
 No clinical PTE (reference) Ref. Ref. Ref. Ref.
 Presence of clinical PTE a −1.2 (−2.2 – −0.3) 0.011 1.5 (− 10.4–13.5) 0.363
  1. PTE pulmonary thromboembolism; CI confidence interval; APACHE Acute Physiology and Chronic Health Evaluation; BMI body mass index; CRP C-reactive-protein
  2. aA negative regression coefficient indicates that the fibrinogen concentration is overall lower over time compared to the reference group