Table 3 Stratified for men and women. The linear mixed-effects models show the average difference in fibrinogen, D-dimer, CRP, and ferritin concentration development over time in mechanically ventilated patients with and without clinical pulmonary thromboembolism
Model | Regression coefficient (95% CI) Men (n = 33) Fibrinogen (g/L) | p-value | Regression coefficient (95% CI) Women (n = 6) Fibrinogen (g/L) | p-value |
|---|---|---|---|---|
Model 1: Crude | ||||
 No clinical PTE (reference) | Ref. | Ref. | Ref. | Ref. |
 Presence of clinical PTE * | −0.05 (− 1.2–1.1) | 0.926 | 0.425 (−1.4–2.3) | 0.564 |
Model 2: Model 1 additionally adjusted for age, sex, Apache -II score, BMI (continuous, kg/m2) and nadroparin dosing (dose in units), and unfractionated heparin usage (yes/no) | ||||
 No clinical PTE (reference) | Ref. | Ref. | Ref. | Ref. |
 Presence of clinical PTE a | −1.3 (− 2.2 – − 0.4) | 0.006 | 1.3 (− 11.6–14.2) | 0.427 |
Model 3: Model 2 additionally adjusted for CRP and ferritin or fibrinogen and D-dimer | ||||
 No clinical PTE (reference) | Ref. | Ref. | Ref. | Ref. |
 Presence of clinical PTE a | −1.2 (−2.2 – −0.3) | 0.011 | 1.5 (− 10.4–13.5) | 0.363 |