Table 1 The clinical characteristics of enrolled patients with acute coronary syndromes
From: Prevalence and impact of fibrinolytic dysregulation in patients with acute coronary syndromes
Variable | Total | Fibrinolysis | P-value | ||
|---|---|---|---|---|---|
Physiologic | Shutdown | Hyper- | |||
n | 338 | 99 | 163 | 76 | – |
Males, n(%) | 272 (80.5) | 84 (30.9) | 134 (49.3) | 54 (19.9) | 0.055 |
Age, years | 62.5 ± 12.8 | 62.6 ± 13.3 | 62.4 ± 13.1 | 62.5 ± 11.6 | 0.457 |
Smoking, n(%) | 199 (58.9) | 59 (59.6) | 97 (59.5) | 43 (56.6) | 0.899 |
Hypertension, n(%) | 150 (44.4) | 41 (41.4) | 70 (42.9) | 39 (51.3) | 0.373 |
Diabetes, n(%) | 76 (22.5) | 28 (28.3) | 30 (18.4) | 18 (23.7) | 0.171 |
STEMI, n(%) | 137 (40.5) | 38 (38.4) | 69 (42.3) | 30 (39.5) | 0.801 |
Stroke, n(%) | 12 (3.6) | 3 (3.0) | 5 (3.1) | 4 (5.3) | 0.657 |
CKD, n(%) | 22 (6.5) | 9 (9.1) | 8 (4.9) | 5 (6.6) | 0.412 |
CHF, n(%) | 11 (3.2) | 3 (3.0) | 7 (4.3) | 1 (1.3) | 0.476 |
SBP, mmHg | 134.5 ± 23.9 | 132.5 ± 25.8 | 134.3 ± 22.7 | 137.2 ± 23.9 | 0.202 |
Heart rate, beats/min | 80.6 ± 16.5 | 81.0 ± 18.23 | 80.5 ± 16.1 | 80.4 ± 15.2 | 0.254 |
BMI, kg/m2 | 24.4 ± 3.5 | 24.0 ± 3.0 | 24.7 ± 3.9 | 24.1 ± 3.1 | 0.228 |
Troponin I, ng/ml | 13.3 (0.94–60.0) | 18.5 (1.3–66.8) | 13.7 (1.6–74.2) | 7.55 (0.33–52.0) | 0.229 |
Serum Creatine, umol/L | 87.9 (71.4–112.9) | 87.9 (73.1–99.4) | 86.3 (70.1–119.5) | 90.1 (72.5–129.0) | 0.036 |
ALT, U/L | 31.2 (19.3–54.4) | 31.2 (20.0–54.7) | 31.8 (19.2–54.6) | 29 (18.8–50.2) | 0.762 |
Leukocytes, ×109/L | 9.8 ± 3.7 | 9.6 ± 3.7 | 10.0 ± 3.9 | 9.4 ± 3.2 | 0.244 |
Hemoglobin, g/L | 129.0 ± 22.5 | 130.9 ± 20.2 | 130.1 ± 23.5 | 124.2 ± 22.9 | 0.463 |
Platelets, ×109/L | 217.7 ± 66.6 | 214.1 ± 69.3 | 214.9 ± 63.5 | 228.3 ± 69.1 | 0.637 |
Total cholesterol, mmol/L | 4.8 ± 1.4 | 4.7 ± 1.2 | 4.7 ± 1.3 | 5.1 ± 1.9 | 0.026 |
D-dimers, ug/mL | 0.47 (0.28–0.96) | 0.48 (0.30–1.22) | 0.47 (0.27–0.91) | 0.43 (0.30–0.85) | 0.790 |
Fibrinogen, g/L | 3.97 ± 1.27 | 3.79 ± 1.00 | 4.06 ± 1.46 | 3.98 ± 1.13 | 0.041 |
APTT, sec | 39.1 ± 12.8 | 39.1 ± 11.7 | 38.8 ± 9.9 | 39.6 ± 18.6 | 0.504 |
PT, sec | 13.6 ± 3.4 | 13.2 ± 1.8 | 13.9 ± 4.5 | 13.4 ± 1.7 | 0.104 |
R-time, min | 5.53 ± 2.79 | 5.13 ± 2.09 | 6.04 ± 3.46 | 4.98 ± 1.45 | 0.003 |
K-time, min | 1.66 ± 1.00 | 1.54 ± 0.55 | 1.86 ± 1.31 | 1.38 ± 0.46 | <0.001 |
Angle, degree | 67.41 ± 8.90 | 68.32 ± 6.51 | 65.5 ± 10.7 | 70.28 ± 5.93 | <0.001 |
MA, mm | 64.37 ± 7.99 | 64.32 ± 6.12 | 64.67 ± 9.15 | 63.82 ± 7.51 | 0.082 |
LY30, % | 0.8 (0–2.6) | 1.6 (1.10–2.10) | 0 (0–0.20) | 5.05 (3.92–7.40) | 0.001 |
ADP-IR, % | 47.6 ± 32.8 | 45.7 ± 32.9 | 50.8 ± 33.1 | 43.4 ± 31.7 | 0.736 |
AA-IR, % | 71.2 ± 28.9 | 66.6 ± 32.3 | 70.4 ± 28.3 | 78.4 ± 24.5 | 0.009 |