From: Pregnancy complications in G20210A mutation carriers associated with high prothrombin activity
Statistical values | PC (n = 15) | 7–8 weeks n = 15 | 12–13 weeks n = 15 | 18–19 weeks n = 15 | 22–23 weeks n = 14 | 27–28 weeks n = 11 | 32–33 weeks n = 10 |
---|---|---|---|---|---|---|---|
Prothrombin activity cutoff (%) | > 171.0 | > 181.3 | > 180.0 | > 180.6 | > 191.5 | > 196.0 | > 192.1 |
Sensitivity | 80 | 93.3 | 95 | 100 | 100 | 100 | 72.7 |
Specificity | 87.8 | 70 | 71 | 55.6 | 69.2 | 93.3 | 75 |
Area under ROC curve (AUC) | 0.863 | 0.840 | 0.792 | 0.756 | 0.788 | 0.958 | 0.741 |
95% CI for AUC | 0.779–0.925 | 0.677–0.942 | 0.609–0.916 | 0.575–0.888 | 0.654–0.889 | 0.844–0.996 | 0.605–0.849 |
(p) | < 0.0001 | < 0.0001 | 0.0022 | 0.0031 | < 0.0001 | < 0.0001 | 0.002 |