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Table 3 The results of ROC analysis to predict early and/or severe preeclampsia at different stages of pregnancy using the level of prothrombin activity as a marker for patients with prothrombin G20210A mutation

From: Pregnancy complications in G20210A mutation carriers associated with high prothrombin activity

Statistical values PC (n = 15) 7–8 weeks
n = 15
12–13 weeks
n = 15
18–19 weeks
n = 15
22–23 weeks
n = 14
27–28 weeks
n = 11
32–33 weeks
n = 10
Prothrombin activity cutoff (%) > 171.0 > 181.3 > 180.0 > 180.6 > 191.5 > 196.0 > 192.1
Sensitivity 80 93.3 95 100 100 100 72.7
Specificity 87.8 70 71 55.6 69.2 93.3 75
Area under ROC curve (AUC) 0.863 0.840 0.792 0.756 0.788 0.958 0.741
95% CI for AUC 0.779–0.925 0.677–0.942 0.609–0.916 0.575–0.888 0.654–0.889 0.844–0.996 0.605–0.849
(p) < 0.0001 < 0.0001 0.0022 0.0031 < 0.0001 < 0.0001 0.002