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Table 3 The results of ROC analysis to predict early and/or severe preeclampsia at different stages of pregnancy using the level of prothrombin activity as a marker for patients with prothrombin G20210A mutation

From: Pregnancy complications in G20210A mutation carriers associated with high prothrombin activity

Statistical values

PC (n = 15)

7–8 weeks

n = 15

12–13 weeks

n = 15

18–19 weeks

n = 15

22–23 weeks

n = 14

27–28 weeks

n = 11

32–33 weeks

n = 10

Prothrombin activity cutoff (%)

> 171.0

> 181.3

> 180.0

> 180.6

> 191.5

> 196.0

> 192.1

Sensitivity

80

93.3

95

100

100

100

72.7

Specificity

87.8

70

71

55.6

69.2

93.3

75

Area under ROC curve (AUC)

0.863

0.840

0.792

0.756

0.788

0.958

0.741

95% CI for AUC

0.779–0.925

0.677–0.942

0.609–0.916

0.575–0.888

0.654–0.889

0.844–0.996

0.605–0.849

(p)

< 0.0001

< 0.0001

0.0022

0.0031

< 0.0001

< 0.0001

0.002