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Table 1 Clinical characterization and laboratory values of ICU patients (n = 18)

From: Point of care diagnostic of hypercoagulability and platelet function in COVID-19 induced acute respiratory distress syndrome: a retrospective observational study

Parameters day 1 day 4 day 7 day 14 ICU stay
Age [years]      61 (51–69)
Body mass index [kg/m2]      29.3 (25.3–34.6)
Duration of ICU stay [days]      23 (14–34)
Duration of mechanical ventilation [days]      19 (11–30)
90-day survival [%]      72.2
SOFA (0–24) 12 (10–15) 16 (12–18) 15 (10–16) 12 (5–16)  
APACHE II (0–71) 32 (25–36) 34 (26–39) 32 (29–38) 31 (23–36)  
PaO2/FiO2 [mmHg] 122 (87–189) 102 (89–158) 138 (106–167) 149 (132–198)  
White blood count [103/µl] (5–10) 9.2 (6.6–11.3) 10.7 (7.7–16.1) 11.9 (7.4–16.3) 11.1 (10.0-15.8)  
Red blood count [106/µl] (4–6) 3.58 (3.14–3.81) 3.11 (2.91–3.45) 3.21 (2.91–3.28) 3.02 (2.74–3.30)  
Hemoglobin [g/dl] (female: 12–16, male: 14–18) 10.0 (8.9–11.1) 9.1 (8.3–10.0) 9.0 (8.6–9.2) 9.2 (8.5–9.4)  
Hematocrit [%] (female: 35–47, male: 42–50) 32.4 (28.3–33.8) 29.0 (26.2–31.1) 29.9 (27.2–30.5) 27.5 (26.0-30.1)  
Platelet count [103/µl] (150–450) 211 (131–282) 206 (145–232) 232 (165–340) 261 (181–328)  
Mean platelet volume [fl] (9.7–11.9) 11.0 (10.3–11.8) 11.1 (10.6–11.5) 11.5 (11.2–12.0) 11.8 (11.1–13.1)  
aPTT [sec] (23–36) 39.6 (37.5–46.2) 46.4 (40.2–56.6) 50.6 (32.9–58.2) 42.5 (31.3–54.1)  
PT [sec] (10–12) (n = 17) 11.9 (10.1–12.4) 11.9 (10.2–12.2) 11.2 (10.2–12.0) 11.8 (10.5–12.3)  
INR (0,85 − 1,18) 0.99 (0.94–1.06) 1.01 (0.94–1.06) 0.98 (0.93–1.04) 1.04 (0.99–1.08)  
Quick [%] (70–130) 94 (88–112) 94 (86–113) 103 (92–118) 100 (88–108)  
Fibrinogen [g/l] (2.1-4.0) 6.0 (5.5–7.2) 6.5 (5.7–7.5) 6.1 (4.8–8.4) 5.6 (5.0-6.9)  
D-dimer [mg/l] (< 0.5) 4.7 (2.6–7.3) 2.9 (1.7–5.4) 4.5 (2.3–8.6) 7.2 (4.5–11.4)  
AT [%] (75–125 %) 79 (73–90) 91 (79–103) 106 (87–119) 96 (77–108)  
DIC Score (n = 17) 3 (3–3) 3 (2–3) 3 (3–3) 3 (3–3)  
IL-6 [pg/ml] (< 7) 224 (127–511) 247 (81–547) 101 (27–212) 74 (37–308)  
C-reactive protein [mg/dl] (< 0.5) 23.3 (16.1–27.7) 25.14 (14.3–32.5) 18.8 (7.7–29.1) 13.4 (7.7–17.5)  
Procalcitonin [ng/ml] (< 0.5) 1.53 (0.72–3.62) 1.85 (0.50–6.27) 1.45 (0.39–3.86) 1.83 (0.27–2.32)  
Creatinine [mg/dl] (< 1.17) 1.08 (0.80–1.85) 1.08 (0.80–1.85) 1.24 (0.81–2.02) 1.06 (0.86–1.58)  
Anti-Xa level [IU/mL] 0.46 (0.13–0.78) (n = 2) 0.38 (0.21–0.55) (n = 5) 0.46 (0.32–0.60) (n = 7) 0.59 (0.37–0.76) (n = 4)  
  1. Clinical characterization and laboratory values of ICU patients (total n=18) in course of ICU stay.
  2. Clinical scores and laboratory values at days 1, 4, 7 and 14 after admission to ICU. Values are expressed as median and IQR. Disseminated Intravascular Coagulation (DIC) scores are calculated from platelet count, prothrombin time, fibrinogen and D-dimers according to guidelines of the International Society on Thrombosis and Haemostasis (ISTH) [35]. Units are displayed in square brackets and reference values in round brackets. Abbreviations: SOFA Sequential Organ Failure Assessment Score, APACHE II Acute Physiology And Chronic Health Evaluation Score II, PaO2 oxygen partial pressure, FiO2 fraction of inspired oxygen, aPTT activated Partial Thromboplastin Time, PT Prothrombin Time, INR International Normalized Ratio, AT Antithrombin, IL-6 Interleukin 6.