From: Risk factors of thrombosis in Chinese subjects with acute promyelocytic leukemia
Gene mutations | APL patients with thrombosis(7) | APL patients without thrombosis(37) | P values |
---|---|---|---|
WT-1 | 5 (71.4%) | 9 (24.3%) | 0.01 |
FLT3-ITD | 6 (85.7%) | 8 (21.6%) | 0.0008 |
DNMT3A | 0 (0%) | 3 (8.1%) | 0.44 |
TET2 | 2 (28.6%) | 6 (16.2%) | 0.43 |
IDH1 | 1 (14.3%) | 3 (8.1%) | 0.6 |
IDH2 | 0 (0%) | 1 (2.7%) | 0.66 |
NRAS | 0 (0%) | 1 (2.7%) | 0.66 |
ASXL1 | 1 (14.3%) | 6 (16.2%) | 0.9 |
TP53 | 0 (0%) | 0 (0%) | – |
RUNX1 | 0 (0%) | 0 (0%) | – |
NPM1 | 0 (0%) | 0 (0%) | – |
CEBPA | 0 (0%) | 0 (0%) | – |
C-kit | 0 (0%) | 0 (0%) | – |
dupMLL | 0 (0%) | 0 (0%) | – |