Temporal change in Syndecan-1 as a therapeutic target and a biomarker for the severity classification of COVID-19

Thrombosis Journal

Table 1 Therapeutic Strategy for critical COVID-19

● Therapeutic strategy for critical COVID-19 [16]
1) Mechanical ventilator (primary setting)	mode	pressure control
	PEEP	10-15 cmH₂O
	Driving Pressure	6-8/BW (kg) cmH₂O
	Respiratory Rate	12-16/min.
2) Antiviral therapy	Loponavir/Ritonavir, Fapiviravir, Remdesivir [17]	10 days
3) Systemic steroid therapy	Dexamethasone [18]	10 days
4) Anticoagulant therapy	UFH with therapeutic dose according to APTT (1.5-2 times as normal)
5) Protection for DVT	Intermittent air compression and elastic stocking
6) Antibiotics	for CAP or secondary bacterial or fungus infection
7) Rehabilitation	early intervention by NS, PT and OT
8) Nutrition	early intervention via tube feeding or TPN
9) Supportive therapy	sedation,catecholamine support etc. via central venous catheter Extracorporeal membrane oxygenation (ECMO)

BW Body Weight, PEEP positive end-expiratory pressure, UFH unfractionated heparin, APTT activated partial thromboplastin time, CAP community associated pneumonia, NS nurse, PT physical therapist, OT occupational therapist, TPN total parenteral nutrition

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