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Table 1 Therapeutic Strategy for critical COVID-19

From: Temporal change in Syndecan-1 as a therapeutic target and a biomarker for the severity classification of COVID-19

Therapeutic strategy for critical COVID-19 [16]
1) Mechanical ventilator (primary setting) mode pressure control
PEEP 10-15 cmH2O
Driving Pressure 6-8/BW (kg) cmH2O
Respiratory Rate 12-16/min.
2) Antiviral therapy Loponavir/Ritonavir, Fapiviravir, Remdesivir [17] 10 days
3) Systemic steroid therapy Dexamethasone [18] 10 days
4) Anticoagulant therapy UFH with therapeutic dose according to APTT (1.5-2 times as normal)
5) Protection for DVT Intermittent air compression and elastic stocking
6) Antibiotics for CAP or secondary bacterial or fungus infection  
7) Rehabilitation early intervention by NS, PT and OT  
8) Nutrition early intervention via tube feeding or TPN  
9) Supportive therapy sedation,catecholamine support etc. via central venous catheter
Extracorporeal membrane oxygenation (ECMO)
  1. BW Body Weight, PEEP positive end-expiratory pressure, UFH unfractionated heparin, APTT activated partial thromboplastin time, CAP community associated pneumonia, NS nurse, PT physical therapist, OT occupational therapist, TPN total parenteral nutrition