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Table 1 ROC Curve Analyzes

From: Point-of-care detection and differentiation of anticoagulant therapy - development of thromboelastometry-guided decision-making support algorithms

Discrimination Variable AUC (SE) P-value Optimum cutoff Sensitivity Specificity
CON + DIL vs. OAC CTEXTEM 0.915 (0.027) < 0.001 91.5 0.74 0.96
CTFIBTEM 0.858 (0.040) < 0.001 75.5 0.82 0.84
CTTFTEM 0.991 (0.006) < 0.001 194.5 0.94 0.98
A5FIBTEM 0.814 (0.042) < 0.001 8.5 0.98 0.54
A5TFTEM 0.714 (0.051) < 0.001 36.5 0.88 0.48
(CTEXTEM x A5FIBTEM) / 100 0.952 (0.018) < 0.001 9.3 0.96 0.80
(CTTFTEM x A5FIBTEM) / 100 0.972 (0.013) < 0.001 20.9 0.96 0.86
(CTTFTEM x A5TFTEM) / 100 0.991 (0.006) < 0.001 65.8 1.00 0.92
(CTTFTEM x CTHEPTEM) / 1000 0.984 (0.009) < 0.001 36.5 0.94 0.94
CON vs. DIL CTEXTEM 0.380 (0.079) 0.154 58.5 0.90 0.20
CTFIBTEM 0.482 (0.084) 0.828 63.0 0.75 0.37
A5EXTEM 0.934 (0.350) < 0.001 38.5 0.90 0.90
A5FIBTEM 0.919 (0.050) < 0.001 11.5 0.85 0.90
(CTTFTEM x A5FIBTEM) / 100 0.920 (0.051) < 0.001 13.4 0.90 0.93
(CTTFTEM x A5TFTEM) / 100 0.908 (0.056) < 0.001 47.3 0.90 0.93
DXaIs vs. DTI + VKA CTEXTEM 0.782 (0.067) 0.001 129.0 0.70 0.85
CTFIBTEM 0.827 (0.061) < 0.001 140.5 0.70 0.95
CTHEPTEM 0.462 (0.880) 0.649 167.5 1.00 0.10
CTTFTEM 0.950 (0.033) < 0.001 355.5 0.90 0.95
CTECATEM 0.288 (0.083) 0.012 49.0 1.00 0.05
CT-ratioTFTEM/ECATEM 0.970 (0.021) < 0.001 3.56 0.93 0.90
CTHEPTEM/A5FIBTEM 0.450 (0.850) 0.552 15.8 0.50 0.60
(CTTFTEM x CTECATEM) / 1000 0.717 (0.079) 0.010 24.3 0.93 0.50
(CTHEPTEM x A5FIBTEM) / 100 0.512 (0.083) 0.890 54.6 0.40 0.85
DTI vs. DXaIs + VKA CTEXTEM 0.409 (0.086) 0.376 86.0 0.90 0.25
CTFIBTEM 0.388 (0.083) 0.275 82.0 0.90 0.28
CTHEPTEM 0.746 (0.093) 0.017 263.5 0.70 0.45
CTTFTEM 0.124 (0.051) < 0.001 149.0 1.00 0.00
CTECATEM 0.900 (0.095) < 0.001 111.5 0.90 1.00
CT-ratioTFTEM/ECATEM 0.025 (0.026) < 0.001 9.9 0.00 1.00
CTHEPTEM/A5FIBTEM 0.740 (0.078) 0.020 12.7 1.00 0.48
(CTTFTEM x CTECATEM) /1000 0.552 (0.109) 0.611 33.3 0.70 0.53
(CTHEPTEM x A5FIBTEM) / 100 0.565 (0.095) 0528 33.8 0.80 0.43
VKA vs. DXaIs+DTI CTEXTEM 0.169 (0.056) 0.001 67.0 1.00 0.05
CTFIBTEM 0.123 (0.048) < 0.001 56.0 1.00 0.00
CTHEPTEM 0.311 (0.095) 0.067 438.5 0.10 0.98
CTTFTEM 0.201 (0.060) 0.004 190.0 1.00 0.08
CTECATEM 0.419 (0.089) 0.431 67.5 1.00 0.08
CT-ratioTFTEM/ECATEM 0.270 (0.069) 0.026 1.76 1.00 0.23
CTHEPTEM/A5FIBTEM 0.335 (0.980) 0.109 38.0 0.10 1.00
(CTTFTEM x CTECATEM) /1000 0.123 (0.050) < 0.001 15.5 1.00 0.05
(CTHEPTEM x A5FIBTEM) / 100 0.418 (0.083) 0.423 24.3 1.00 0.15
DTI vs. VKA CTHEPTEM 0.810 (0.107) 0.190 216.5 0.90 0.70
CTECATEM 0.900 (0.095) 0.002 110.0 0.90 1.00
(CTECATEM x CTHEPTEM) / 1000 0.910 (0.064) 0.002 27.7 0.80 0.90
DTI vs. DXaIs CTECATEM 0.900 (0.095) < 0.001 111.5 0.90 1.00
CT-ratioTFTEM/ECATEM 0.993 (0.009) < 0.001 3.56 0.93 1.00
(CTECATEM x CTHEPTEM) / 1000 0.880 (0.073) < 0.001 37.9 0.70 1.00
DXaIs vs. VKA CTEXTEM 0.845 (0.061) 0.001 125.5 0.73 1.00
CTFIBTEM 0.897 (0.050) < 0.001 106.5 0.83 1.00
CTHEPTEM 0.648 (0.102) 0.165 222.5 0.60 0.80
CTTFTEM 0.948 (0.036) < 0.001 355.5 0.90 1.00
CT-ratioTFTEM/ECATEM 0.947 (0.037) < 0.001 3.60 0.93 0.90
(CTTFTEM x CTHEPTEM) / 1000 0.910 (0.047) < 0.001 67.6 0.90 0.80
  1. ROC, receiver operating characteristics; AUC, area under the curve; SE, standard error; CT, coagulation time; CON, controls; DIL, dilutional coagulopathy; OAC, oral anticoagulants; DXaI, direct factor Xa inhibitors (apixaban, edoxaban, rivaroxaban); DTI, direct thrombin inhibitor (dabigatran); VKA, vitamin K-antagonist (phenprocoumon)
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Thrombosis Journal

ISSN: 1477-9560

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