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Table 1 ROC Curve Analyzes

From: Point-of-care detection and differentiation of anticoagulant therapy - development of thromboelastometry-guided decision-making support algorithms

Discrimination

Variable

AUC (SE)

P-value

Optimum cutoff

Sensitivity

Specificity

CON + DIL vs. OAC

CTEXTEM

0.915 (0.027)

< 0.001

91.5

0.74

0.96

CTFIBTEM

0.858 (0.040)

< 0.001

75.5

0.82

0.84

CTTFTEM

0.991 (0.006)

< 0.001

194.5

0.94

0.98

A5FIBTEM

0.814 (0.042)

< 0.001

8.5

0.98

0.54

A5TFTEM

0.714 (0.051)

< 0.001

36.5

0.88

0.48

(CTEXTEM x A5FIBTEM) / 100

0.952 (0.018)

< 0.001

9.3

0.96

0.80

(CTTFTEM x A5FIBTEM) / 100

0.972 (0.013)

< 0.001

20.9

0.96

0.86

(CTTFTEM x A5TFTEM) / 100

0.991 (0.006)

< 0.001

65.8

1.00

0.92

(CTTFTEM x CTHEPTEM) / 1000

0.984 (0.009)

< 0.001

36.5

0.94

0.94

CON vs. DIL

CTEXTEM

0.380 (0.079)

0.154

58.5

0.90

0.20

CTFIBTEM

0.482 (0.084)

0.828

63.0

0.75

0.37

A5EXTEM

0.934 (0.350)

< 0.001

38.5

0.90

0.90

A5FIBTEM

0.919 (0.050)

< 0.001

11.5

0.85

0.90

(CTTFTEM x A5FIBTEM) / 100

0.920 (0.051)

< 0.001

13.4

0.90

0.93

(CTTFTEM x A5TFTEM) / 100

0.908 (0.056)

< 0.001

47.3

0.90

0.93

DXaIs vs. DTI + VKA

CTEXTEM

0.782 (0.067)

0.001

129.0

0.70

0.85

CTFIBTEM

0.827 (0.061)

< 0.001

140.5

0.70

0.95

CTHEPTEM

0.462 (0.880)

0.649

167.5

1.00

0.10

CTTFTEM

0.950 (0.033)

< 0.001

355.5

0.90

0.95

CTECATEM

0.288 (0.083)

0.012

49.0

1.00

0.05

CT-ratioTFTEM/ECATEM

0.970 (0.021)

< 0.001

3.56

0.93

0.90

CTHEPTEM/A5FIBTEM

0.450 (0.850)

0.552

15.8

0.50

0.60

(CTTFTEM x CTECATEM) / 1000

0.717 (0.079)

0.010

24.3

0.93

0.50

(CTHEPTEM x A5FIBTEM) / 100

0.512 (0.083)

0.890

54.6

0.40

0.85

DTI vs. DXaIs + VKA

CTEXTEM

0.409 (0.086)

0.376

86.0

0.90

0.25

CTFIBTEM

0.388 (0.083)

0.275

82.0

0.90

0.28

CTHEPTEM

0.746 (0.093)

0.017

263.5

0.70

0.45

CTTFTEM

0.124 (0.051)

< 0.001

149.0

1.00

0.00

CTECATEM

0.900 (0.095)

< 0.001

111.5

0.90

1.00

CT-ratioTFTEM/ECATEM

0.025 (0.026)

< 0.001

9.9

0.00

1.00

CTHEPTEM/A5FIBTEM

0.740 (0.078)

0.020

12.7

1.00

0.48

(CTTFTEM x CTECATEM) /1000

0.552 (0.109)

0.611

33.3

0.70

0.53

(CTHEPTEM x A5FIBTEM) / 100

0.565 (0.095)

0528

33.8

0.80

0.43

VKA vs. DXaIs+DTI

CTEXTEM

0.169 (0.056)

0.001

67.0

1.00

0.05

CTFIBTEM

0.123 (0.048)

< 0.001

56.0

1.00

0.00

CTHEPTEM

0.311 (0.095)

0.067

438.5

0.10

0.98

CTTFTEM

0.201 (0.060)

0.004

190.0

1.00

0.08

CTECATEM

0.419 (0.089)

0.431

67.5

1.00

0.08

CT-ratioTFTEM/ECATEM

0.270 (0.069)

0.026

1.76

1.00

0.23

CTHEPTEM/A5FIBTEM

0.335 (0.980)

0.109

38.0

0.10

1.00

(CTTFTEM x CTECATEM) /1000

0.123 (0.050)

< 0.001

15.5

1.00

0.05

(CTHEPTEM x A5FIBTEM) / 100

0.418 (0.083)

0.423

24.3

1.00

0.15

DTI vs. VKA

CTHEPTEM

0.810 (0.107)

0.190

216.5

0.90

0.70

CTECATEM

0.900 (0.095)

0.002

110.0

0.90

1.00

(CTECATEM x CTHEPTEM) / 1000

0.910 (0.064)

0.002

27.7

0.80

0.90

DTI vs. DXaIs

CTECATEM

0.900 (0.095)

< 0.001

111.5

0.90

1.00

CT-ratioTFTEM/ECATEM

0.993 (0.009)

< 0.001

3.56

0.93

1.00

(CTECATEM x CTHEPTEM) / 1000

0.880 (0.073)

< 0.001

37.9

0.70

1.00

DXaIs vs. VKA

CTEXTEM

0.845 (0.061)

0.001

125.5

0.73

1.00

CTFIBTEM

0.897 (0.050)

< 0.001

106.5

0.83

1.00

CTHEPTEM

0.648 (0.102)

0.165

222.5

0.60

0.80

CTTFTEM

0.948 (0.036)

< 0.001

355.5

0.90

1.00

CT-ratioTFTEM/ECATEM

0.947 (0.037)

< 0.001

3.60

0.93

0.90

(CTTFTEM x CTHEPTEM) / 1000

0.910 (0.047)

< 0.001

67.6

0.90

0.80

  1. ROC, receiver operating characteristics; AUC, area under the curve; SE, standard error; CT, coagulation time; CON, controls; DIL, dilutional coagulopathy; OAC, oral anticoagulants; DXaI, direct factor Xa inhibitors (apixaban, edoxaban, rivaroxaban); DTI, direct thrombin inhibitor (dabigatran); VKA, vitamin K-antagonist (phenprocoumon)
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Thrombosis Journal

ISSN: 1477-9560

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