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Table 2 Coagulation function indexs of proband and family members in hereditary protein S deficiency family

From: A thrombophilia family with protein S deficiency due to protein translation disorders caused by a Leu607Ser heterozygous mutation in PROS1

Items

Propositus (III5)

Father

(II7)

Mother

(II8)

Brother

(III6)

Member

(II1)

Member (II6)

Member (II10)

reference value

PT (s)

13.3

11.2

11.8

12.3

9.8

11.9

12.1

9.9–12.9

APTT (s)

27.9

26.4

28.8

32

27.1

24.3

23.9

23.3–32.5

TT (s)

15.5

15.8

17.0

30.9

17.1

16.4

19.2

14–21

Fg (g/L)

2.57

2.32

2.7

1.9

2.41

2.79

2.34

1.8–3.5

D-dimer

25.8

0.24

13.2

15.5

0.23

0.01

0.01

0–0.55

TPS (mg/L)

67

208

85

71

–

–

–

160–260

FPS (mg/L)

19

66

22

23

–

–

–

48–67

PS(%)

< 16

84.4

< 16

16.7

102.7

97.4

112.3

Male:75–130 Female:52–118

PC(%)

66.9

90.1

100.2

60.2

113.4

124.2

98.1

70–140

AT-III(%)

92

107.6

97.4

85.9

121.2

109.1

97.1

75–125

  1. Note: PT prothrombin time; INR international normalized ratio; APTT activated partial thromboplastin time; TT thrombin time; Fg fibrinogen; FDP fibrin degradation products; TPS total protein S; FPS free protein S; PS protein S; PC protein C; AT antithrombin III