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Table 2 Coagulation function indexs of proband and family members in hereditary protein S deficiency family

From: A thrombophilia family with protein S deficiency due to protein translation disorders caused by a Leu607Ser heterozygous mutation in PROS1

Items Propositus (III5) Father
(II7)
Mother
(II8)
Brother
(III6)
Member
(II1)
Member (II6) Member (II10) reference value
PT (s) 13.3 11.2 11.8 12.3 9.8 11.9 12.1 9.9–12.9
APTT (s) 27.9 26.4 28.8 32 27.1 24.3 23.9 23.3–32.5
TT (s) 15.5 15.8 17.0 30.9 17.1 16.4 19.2 14–21
Fg (g/L) 2.57 2.32 2.7 1.9 2.41 2.79 2.34 1.8–3.5
D-dimer 25.8 0.24 13.2 15.5 0.23 0.01 0.01 0–0.55
TPS (mg/L) 67 208 85 71 160–260
FPS (mg/L) 19 66 22 23 48–67
PS(%) < 16 84.4 < 16 16.7 102.7 97.4 112.3 Male:75–130 Female:52–118
PC(%) 66.9 90.1 100.2 60.2 113.4 124.2 98.1 70–140
AT-III(%) 92 107.6 97.4 85.9 121.2 109.1 97.1 75–125
  1. Note: PT prothrombin time; INR international normalized ratio; APTT activated partial thromboplastin time; TT thrombin time; Fg fibrinogen; FDP fibrin degradation products; TPS total protein S; FPS free protein S; PS protein S; PC protein C; AT antithrombin III