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Fig. 1 | Thrombosis Journal

Fig. 1

From: Platelet factor 4 polyanion immune complexes: heparin induced thrombocytopenia and vaccine-induced immune thrombotic thrombocytopenia

Fig. 1

The homotetrameric form of PF4 forms a cylindrical structure and comprises of an equatorial ring. Four PF4 monomers (https://www.uniprot.org/uniprot/P02776, accessed on May 2021) form a homotetrameric complex. The homotetrameric complex bind to highly negative molecules and polyanions, including heparin. PF4 structure and images created using Mol* (D. Sehnal, S. Bittrich, M. Deshpande, R. Svobodová, K. Berka, V. Bazgier, S. Velankar, S.K. Burley, J. Koča, A.S. Rose (2021) Mol* Viewer: modern web app for 3D visualization and analysis of large biomolecular structures. Nucleic Acids Research. doi: https://doi.org/10.1093/nar/gkab314). The structure and information of PF4 (1F1F9Q) was obtained from RCSB PDB (https://www.rcsb.org/structure/1f9q, accessed in May 2021)

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Thrombosis Journal

ISSN: 1477-9560

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