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Table 1 Demographic and Clinical Characteristics of Patients with Direct and Indirect ARDS

From: Prevalence, risk, and outcome of deep vein thrombosis in acute respiratory distress syndrome

Characteristic

Total

(N = 225)

Direct ARDS

(N = 111)

Indirect

ARDS (N = 114)

P value

Age (years)

66 ± 17

64 ± 15

67 ± 18

0.192

Male, n (%)

144 (64.0)

84 (75.7)

60 (52.6)

<  0.001

BMI

24.1 (21.6, 26.8)

24.0 (21.0, 26.2)

24.4 (21.9, 27.0)

0.274

Bedridden time (days)

8 (4, 15)

9 (5, 15)

8 (4, 16)

0.400

APACHE II score

23 (19, 28)

22 (17, 27)

25 (19, 31)

0.010

SOFA score

8 (5, 10)

6 (4, 6)

9 (6, 11)

<  0.001

Laboratory data

 White blood cells (×109/L)

16.9 (12.0, 21.5)

14.3 (10.1, 20.3)

18.2 (14.4, 23.5)

<  0.001

 Neutrophils (×109/L)

14.5 (10.4, 19.7)

12.8 (9.0, 17.7)

16.1 (12.6, 20.8)

<  0.001

 Platelets (×109/L)

183.0 (101.0, 253.5)

190.0 (120.0, 270.0)

167.0 (73.8, 238.0)

0.094

 C-reactive protein (mg/L)

120.0 (89.4, 120.0)

120.0 (85.0, 120.0)

120.0 (92.2, 120.0)

0.391

 Procalcitonin (ng/mL)

5.6 (2.0, 16.2)

4.1 (1.5, 13.5)

7.3 (3.0, 21.2)

0.008

 Serum creatinine (μmol/L)

116.7 (66.6, 209.5)

90.5 (65.0, 193.0)

136.9 (67.9, 248.8)

0.019

 D-dimer (μg/ml)

1.9 (0.9, 3.8)

1.3 (0.6, 2.5)

2.4 (1.3, 5.3)

<  0.001

 PaO2/FiO2

158 (103, 199)

136 (80, 186)

170 (130, 208)

<  0.001*

 Mild, n (%)

54 (24.0)

22 (19.8)

32 (28.1)

<  0.001#

 Moderate, n (%)

116 (51.6)

49 (44.1)

67 (58.8)

 

 Severe, n (%)

55 (24.4)

40 (36.0)

15 (13.2)

 

 DVT, n (%)

90 (40.0%)

44 (39.6)

46 (40.4)

0.913

 ICU length of stay (days)

11 (6, 24)

13 (7, 25)

10 (5, 24)

0.103

 Hospital length of stay (days)

19 (12, 32)

17 (10, 29)

22 (13, 34)

0.055

 Mortality, n (%)

77 (34.2)

36 (32.4)

41 (36.0)

0.577

  1. Data are mean ± SD, median (IQR) or n (%). P values comparing Direct and Indirect ARDS groups were from a two-sample t-test, Mann- Whitney U test, or χ2 test. P <  0.05 was considered statistically significant
  2. *χ2 test comparing Direct and Indirect ARDS groups
  3. #χ2 test comparing all subcategories
  4. Abbreviations: APACHE Acute Physiology and Chronic Health Evaluation, ARDS acute respiratory distress syndrome, BMI body mass index, DVT deep venous thrombosis, FiO2, fraction of inspired oxygen, ICU intensive care unit, IQR interquartile range, mild 200 mmHg<PaO2/FiO2 ≤ 300 mmHg, moderate 100 mmHg<PaO2/FiO2 ≤ 200 mmHg, PaO2 partial pressure of arterial oxygen, SD standard deviation, severe PaO2/FiO2 ≤ 100 mmHg, SOFA Sequential Organ Failure Assessment