Table 2 Demographic, laboratory, and clinical status of patients with APCR abnormality and normal confirmed final diagnosis. (* p < 0.05, ** p < 0.01, *** p < 0.001)
Variable | Study Population | P-value | |
|---|---|---|---|
APCR | Normal | ||
Sex | |||
Female | 189 (65.6%) | 233 (80%) | |
Male | 99 (55.6%) | 52 (18%) | 0.000*** |
Age (mean ± SD and range) | 37 (1–80) | 33.5 (2–84) | 0.001*** |
Familial History of Thrombosis | 87 (52.1%) | 80 (47.9%) | 0.18 |
Type of Disease | |||
Bleeding | 5 (1%) | 0 (0.0%) | 0.99 |
Thrombophilia | 261 (92.3%) | 279 (92.7%) | |
Bleeding and Thrombophilia | 7 (2.5%) | 9 (3.1%) | |
Laboratory Findings | |||
PT | 15.32 ± 4.14 | 13.13 ± 0.74 | 0.008*** |
APTT | 36.44 ± 9.34 | 34.63 ± 3.26 | 0.92 |
Protein C | 94.84 ± 46.58 | 125.89 ± 28.08 | 0.000*** |
Protein S | 64.43 ± 29.96 | 82 ± 20.10 | 0.000*** |
Anti-Thrombin | 97.58 ± 18.36 | 98.52 ± 11.64 | 0.189 |
APCR | 1.47 ± 0.19 | 3.91 ± 0.78 | 0.000*** |
Pregnancy Complications | 0.000*** | ||
Abortion | 65 (22.5%) | 127 (44%) | – |
Eclampsia | 0 | 0 | 0.25 |
Preeclampsia | 3 (1%) | 2 (0.6%) | 0.23 |
Stillbirth | 8 (2.7%) | 11 (3.8%) | 0.06 |
Infertility | 4 (1.3%) | 11 (3.8%) | |
Abortion Time | 0.17 | ||
First Trim | 51 (17.7%) | 112 (38.8%) | |
Second Trim | 11 (3.8%) | 13 (4.5%) | |
Third Trim | 3 (1%) | 2 (0.6%) | |
Thrombotic Complications | |||
DVT | 113 (39.2%) | 36 (12.5%) | 0.000*** |
PE | 27 (9.3%) | 9 (3.1%) | 0.001*** |
Arterial Thrombosis | 16 (5%) | 21 (7.2%) | 0.24 |