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Table 3 Crude and adjusted differences in APCR diagnosis according to demographic, laboratory, and clinical parameters

From: A case-control study on factor V Leiden: an independent, gender-dependent risk factor for venous thromboembolism

Variable

Univariable

Multivariable

Adjusted OR (75% CI)

P-value

Adjusted OR (95% CI)

P-value

Sex

 Female

1

 Male

2.34

0.000*

2.13

0.05**

Age (mean ± SD and range)

1.02

0.001*

1

0.92

Familial History of Thrombosis

1.27

0.18*

1.63

0.24

Laboratory Findings

 PT

1.43

0.001*

0.98

0.94

 APTT

3.03

0.08*

0.99

0.97

 Protein C

0.97

0.000*

0.99

0.20

 Protein S

0.95

0.000*

0.98

0.10

 Anti-Thrombin

0.98

0.09*

1

0.70

 APCR

0.00

0.95

Thrombotic Complications

 DVT

4.52

0.000*

3.53

0.006**

 PE

3.2

0.003*

3.25

0.19

 AT-III

0.74

0.39

1.98

0.48

 Abortion

0.37

0.000*

0.82

0.67

Abortion Time

 First Trim

0.185*

  

 Second Trim

1.85

0.162*

  

 Third Trim

3.29

0.199*

  
  1. PT prothrombin time, APTT activated partial thromboplastin time, APCR activated protein C resistance, AT-III antithrombin III, DVT deep vein thrombosis, PE pulmonary embolism