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Table 3 Differences in coagulation tests, thromboelastography parameters and disease severity scores for 30-day survivors and non-survivors

From: The evolution of clot strength in critically-ill COVID-19 patients: a prospective observational thromboelastography study

Parameter

Reference ranges

Survivors (N = 10)

  

Non-survivors (N = 11)

  

P-value

  
  

Day 1

Day 7

Day 14

Day 1

Day 7

Day 14

Day 1

Day 7

Day 14

D-dimer, mg/L (IQR)

< 0.25

0.80 (0.5–2.46)

 

0.93 (0.7–1.77)

0.82 (0.44–3.1)

 

0.79 (0.47–2.17)

0.88

 

0.94

Fibrinogen, g/L (IQR)

2–4

5 (5–5)b

 

4.95 (4.5–5)

5 (5–5)b

 

5 (5–5)b

1.00

 

1.00

Prothrombin timea, s (IQR)

11–12.5

13.45 (12.9–13.8)

 

12.8 (12.5–13.9)

14 (12.8–15)

 

14 (13.4–14.7)

0.36

 

0.12

Activated partial thromboplastin time, s (IQR)

25.1–36.5

29.7 (28.9–32.6)

 

26.45 (22.4–28.6)

28.8 (27.2–32.7)

 

32.5 (27.8–54.4)

0.45

 

< 0.01

Platelet count, X109/L (IQR)

171–388

348.5 (223–418)

342.5 (209–444)

316 (261–429)

348 (208–458)

334 (311–432)

291 (271–334)

0.76

0.50

0.39

HMA, mm (IQR)

52–68

71.3 (68.5–72.6)

72.3 (69.5–72.8)

70.05 (66.1–72.3)

70.1 (68.2–71.8)

71.3 (69.9–72)

67.3 (65.1–69.4)

0.62

0.46

0.19

FFMA, mm (IQR)

15–32

46.65 (41.2–57.3)

51.95 (43.1–56.7)

44.15 (36.9–50.6)

41.7 (35.5–53.7)

54.4 (45.6–60.4)

51.1 (48.5–59.9)

0.70

0.40

0.07

SOFA score (IQR)

 

4 (4–6)

4 (3–4)

3 (2–4)

4 (3–4)

4 (3–6)

5 (3–6)

0.37

0.29

0.01

Pa02/Fi02 ratio (IQR)

 

94 (60–126)

106.5 (77–142)

168 (129–215)

73 (57–130)

93 (73–120)

104 (68–146)

0.80

0.48

0.06

  1. Table 3: Differences in laboratory coagulation studies, thromboelastography (TEG) parameters and disease severity scores for the 30-day survivors (N = 10) and non-survivors (N = 11) over the 14-day observation. Differences at all time points between 30-day survivors and non-survivors are shown with p-values provided. Data presented as median (IQR). Reference ranges as established by the local laboratory and TEG 6 s operating manual.
  2. HMA Maximum amplitude with citrated kaolin and heparinase, FFMA Functional fibrinogen maximum amplitude, SOFA Sequential organ failure assessment, Pa02/Fi02 Ratio of arterial oxygen partial pressure to fractional inspired oxygen; PT Prothrombin time, aPTT Activated partial thromboplastin time
  3. aPT laboratory control for the duration of the study was 11.7 s
  4. bValue is above the upper measurable limit of fibrinogen in local laboratory