Association of circulating proprotein convertase subtilisin/kexin type 9 concentration, prothrombin time and cardiovascular outcomes: a prospective cohort study

Table 3 Independent determinants of PT or PT-t to log-transformed PCSK9

	Independent variable PT		Independent variable PT-t
	Standardized regression coefficients β	p	Standardized regression coefficients β	p
Model 1^a	−0.192	< 0.001	0.139	< 0.001
Model 2^b	− 0.19	< 0.001	0.137	< 0.001
Model 3^c	−0.189	< 0.001	0.136	< 0.001
Model 4^d	−0.142	< 0.001	0.105	< 0.001
Model 5^e	−0.135	< 0.001	0.100	< 0.001
Model 6^f	−0.135	< 0.001	0.100	< 0.001
Model 7^g	−0.115	< 0.001	0.085	< 0.001

The multivariable regression stepwise models are shown. The log-transformed PCSK9 is the dependent variable.
^aAdjusted for age and sex
^bAdjusted for age, sex, hypertension and diabetes, CAD
^cAdjusted for age, sex, hypertension, diabetes, CAD, smoking status and BMI
^dAdjusted for age, sex, hypertension, diabetes, CAD, smoking status, BMI, TG, TC, HDL-C and LDL-C
^eAdjusted for age, sex, hypertension, diabetes, CAD, smoking status, BMI, TG, TC, HDL-C, LDL-C, glucose and HbA1C
^fAdjusted for age, sex, hypertension, diabetes, CAD, smoking status, BMI, TG, TC, HDL-C, LDL-C, glucose, HbA1C and hsCRP
^gAdjusted for age, sex, hypertension, diabetes, CAD, smoking status, BMI, TG, TC, HDL-C, LDL-C, glucose, HbA1C, hsCRP, fibrinogen, D dimer, platelet, APTT and TT. PT, prothrombin time; PT-t, transformation of prothrombin time (the inverse of the difference between PT and the minimal PT of normal plasma), PCSK9 proprotein convertase subtilisin/Kexin type 9, CAD coronary artery disease, BMI body mass index, TG triglyceride, TC total cholesterol, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, HbA1C hemoglobin A1C, hsCRP high-sensitivity C-reactive protein, ESR erythrocyte sedimentation rate, APTT activated partial thromboplastin time, TT thrombin time

ISSN: 1477-9560