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Table 2 Evolution of CAPS in the described patient

From: A catastrophic seronegative anti-phospholipid syndrome: case and literature review

Organ manifestation Clinical signs Laboratory abnormalities (reference range) Laboratory tests which were normal (negative)
Kidney
 Renal Failure
 Renal infarction
 Renal artery thrombosis
Lung
 Bilateral Pulmonary Embolism
Liver
 Elevated liver enzymes
Peripheral vessel
 Venous thrombosis
 Arterial thrombosis
Spleen
 Splenic infarction
Heart
Obstetric
 fetal death
Polypnea
Absence of pulses in the lower limbs
Minimal neurosensory deficit
Moderate muscle weakness
Hemoglobin: 11,1 g/dL
WBC: 12,20 × 10^9/L
Platelet count 78 × 10^9/L
pH 7.37
pCO2. 20,5 mmHg
HCO3  18,5 mmol/L
Serum creatinine 1,09 mg/dL
AST 106 U/L
ALT 34 U/L
Pancreatic amylase 98 U/L
LDH 950 U/L
Total Creatinine Kinase (CK) 1217 U/L
D-dimers (DD) 4,72 μg/ml
T-Troponin 2137 ng/L
NT-proBNP 4041 pg/mL
Proteinuria 75 mg / dL
Leukocyturia 100 cel / uL
Erythrocyturia 150 cel / uL
12.0–15.3
4.0–11.0
150–450 × 10^9/L
7,35 - 7,45
35–45 mmHg
22–26 mmol/L
0,5–9,0 mg/dL
0–32 U/L
0–33 U/L
13–53 U/L
100–250 U/L
26–192 U/L
0–0,5 μg/ml
<  14 ng/L
<  300 pg/mL
NEGATIVE
NEGATIVE
NEGATIVE
Peripheral blood smear (showed no schizocytes)
INR: 0,97
aPTT: 32,4/29
Fibrinogen: 397 mg/dL (200–400)
Lupic anticoagulant
aCL IgG; aCL IgM
aβ2GPI IgG; aβ2GPI IgM
Antinuclear antibodies
Anti-DS-DNA antibodies
Anti-cytoplasm (MPO; PR3) antibodies
Anti-mitochondria antibody (AMA)
Anti-smooth muscle antibody (ASMA)
anti-citrulline antibody (anti-CCP)
Rheumatoid factor
HLA - B27 normal
Complement count (C3; C4)
Absence of Leiden Factor V mutation
Absence of prothrombine mutation PT20210A
Protein C and protein S
Funcional Antithrombin III
Anti-HIV 1/2 (CHIV Ag/Ab)
Ag-HBs
Anti-HCV
SARS-CoV-2