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Table 4 “Non-criteria” manifestations of antiphospholipid syndrome (adapted from [9, 18])

From: A catastrophic seronegative anti-phospholipid syndrome: case and literature review

Nervous system

Dementia

Seizures

Multiple sclerosis–like illness

Chorea

Myelitis

Brain MRI white matter lesions

Cognitive impairment

Migraine

Skin

Livedo reticularis

Livedoid vasculopathy

Raynaud’s phenomenon

Splinter hemorrhages

Skin ulcers

Heart

Valve vegetations or thickening (Libman-Sacks Endocarditis)

Diastolic dysfunction

Blood

Thrombocytopenia

Hemolytic anemia

Coombs´ test positivity

Kidney

Microangiopathy

Chronic vaso-occlusive lesions (atherosclerosis, glomerular ischemia, interstitial fibrosis, arterial fibrous intimal hyperplasia)

Obstetric

Late intrauterine growth restriction (after 34 weeks)

Late pre-eclampsia (after 34 weeks)

Placental abruption

Placental hematoma

Preterm birth (> 34 to < 37 weeks)

Puerperal pre-eclampsia

Two or more unexplained in vitro fertilization failures

Two unexplained spontaneous abortions < 10 weeks

Other

Superficial vein thrombosis

Amaurosis fugax

Sensorineural hearing loss

Ischemic necrosis of bone

Pulmonary hypertension