Skip to main content

Table 2 Risk factor for recurrent VTE

From: Association between obstructive sleep apnea and venous thromboembolism recurrence: results from a French cohort

Variables Univariable analysis
HR, 95% CI
p-value Multivariable analysis 1
HR, 95% CI
p-value Multivariable analysis 2
HR, 95% CI
p-value
Age range (years)  
  ≤ 50 Ref.   Ref.   Ref.  
 ]50–65] 1.9 (1.3–2.7) < 0.001 1.6 (1.1–2.3) 0.020 1.6 (1.1–2.3) 0.019
  > 65 2.4 (1.8–3.3) < 0.001 2.1 (1.5–3.0) < 0.001 2.2 (1.5–3.0) < 0.001
BMI range (kg/m2)  
  ≤ 25 Ref.   Ref.   Ref.  
 ]25–30] 1.1 (0.8–1.5) 0.48 0.9 (0.7–1.2) 0.58 0.9 (0.7–1.3) 0.69
 ]30–35] 1.1 (0.7–1.6) 0.70 1.0 (0.7–1.5) 0.90 1.0 (0.7–1.5) 0.83
  > 35 0.6 (0.3–1.3) 0.21 0.7 (0.4–1.4) 0.31 0.7 (0.4–1.4) 0.35
Females 0.7 (0.6–0.9) 0.006 0.8 (0.6–1.1) 0.10 0.8 (0.6–1.0) 0.09
Chronic cardiac failure history 0.6 (0.3–1.2) 0.13 0.4 (0.2–0.9) 0.018 0.4 (0.2–0.8) 0.007
Cerebral stroke 0.8 (0.4–1.8) 0.58 0.6 (0.3–1.5) 0.31   
Statins 1.1 (0.7–1.7) 0.69 1.0 (0.7–1.6) 0.93   
Antiplatelet agents 1.0 (0.6–1.5) 0.82 0.9 (0.5–1.4) 0.51   
Smoking 0.9 (0.7–1.2) 0.54     
COPD 1.4 (0.9–2.2) 0.19 1.0 (0.6–1.7) 0.97   
Cancer 1.8 (1.2–2.8) 0.005 2.0 (1.2–3.4) 0.008 2.0 (1.2–3.4) 0.009
Familial history of VTE 1.1 (0.8–1.5) 0.47     
Unprovoked VTE 1.7 (1.3–2.2) < 0.001 2.1 (1.4–3.1) 0.001 2.0 (1.3–3.0) 0.001
OSA history 1.5 (0.7–3.0) 0.33 1.6 (0.7–3.4) 0.26 1.4 (0.6–2.9) 0.42
OSA occurrence 2.8 (0.7–11.3) 0.15 2.4 (0.6–9.8) 0.23 2.3 (0.6–9.6) 0.24
AHI 1.0082 (0.9775–1.040) 0.61     
AHI (continuous range of 10) 1.1 (0.8–1.5) 0.72     
Nocturnal desaturation (hour index) 0.9776 (0.9080–1.052) 0.97     
Anticoagulation duration 0.9995 (0.9989–0.9999) 0.54 0.9974 (0.9989–1.0005) 0.52 0.9998 (0.999–1.0006) 0.56
  1. BMI body mass index, OSA Obstructive Sleep Apnea, AHI apnea hypopnea index, VTE Venous Thromboembolism Multivariable model 1 included variables associated with an increased risk of recurrence in univariable analysis and multivariable model 2 included baseline characteristics distributed differently between OSA and non-OSA patients