Incidence of proximal deep vein thrombosis in medical critical care patients

Thrombosis Journal

Table 3 Factors associated with proximal deep vein thrombosis

Characteristic	No DVT (133)	DVT (25)	p	Multivariable analysis^a
Characteristic	No DVT (133)	DVT (25)	p	Adjusted OR (95% CI)	p
Age, median (IQR), years	61 (45-75)	72 (64-80)	0.04	1.04^b (1.01-1.07)	0.02
Female sex, n (%)	59 (44.4)	17 (68)	0.051	4.05 (1.51-12.3)	0.01
BMI, median (IQR), kg/m²	21.6 (19-24.2)	21.3 (19.2-24.4)	0.83
Acute conditions, n (%)
Acute respiratory failure	107 (80.5)	22 (88)	0.57
Sepsis	104 (78.2)	20 (80)	0.99
Acute kidney injury	37 (27.8)	7 (28)	0.99
Congestive heart failure	9 (6.8)	2 (8)	0.69
COPD with acute exacerbation	8 (6)	2 (8)	0.66
Cerebrovascular accident	9 (6.8)	0 (0)	0.36
ARDS	8 (6)	1 (4)	0.99
APACHE II, mean (SD), points	20.8 (7.7)	22.3 (5.7)	0.26
History of cancer, n (%)	22 (16.5)	3 (12)	0.77
History of previous VTE, n (%)	1 (0.8)	1 (4)	0.29
RRT, n (%)	17 (12.8)	8 (32)	0.03
Duration of RRT, median (IQR), days	2 (1-19)	6.5 (2.5-13.3)	0.68
Platelet transfusion, n (%)	27 (20.3)	1 (4)	0.08	0.07 (0.003-0.43)	0.02
Use of vasopressor or inotropes, n (%)	89 (66.9)	18 (72)	0.79
Use of NMBA, n (%)	18 (13.6)	6 (24)	0.22
Central venous line, n (%)	68 (51.1)	17 (68)	0.18
Internal jugular vein	59 (44.4)	14 (56)	0.94
Femoral vein	15 (11.3)	9 (36)	0.004	11.18 (3.19-44.83)	< 0.001
Subclavian vein	5 (3.8)	3 (12)	0.11
Cubital vein	8 (6)	1 (4)	0.99
Mechanical ventilation, n (%)	111 (83.5)	22 (88)	0.77
Clinical probability at first 48 h, n (%)
Low	106 (79.7)	15 (60)	0.02
Moderate	23 (17.3)	6 (24)
High	4 (3)	4 (16)

APACHE = acute physiology, age, chronic health evaluation, ARDS = acute respiratory distress syndrome, BMI = body mass index, CI = confidence interval, COPD = chronic obstructive pulmonary disease, DVT = deep vein thrombosis, IQR = interquartile range, NMBA = neuromuscular blocking agent, OR = odds ratio RRT = renal replacement therapy, VTE = venous thromboembolism
^aArea under the receiver operating characteristic curve (95% CI) of multivariable analysis = 0.72 (95% CI 0.60–0.85)
^bper 1 point increase

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