Fig. 1

Changes in coagulation/fibrinolysis markers in patients with sepsis-associated DIC before and after rTM administration. Blood samples were collected from the eight patients with sepsis-associated DIC before and after administration of rTM on day 1 and day 2. (A) Prothrombin fragment 1 + 2 (F1 + 2), (B) soluble fibrin (SF), (C) antithrombin (AT), (D) protein S (PS), (E) plasminogen activator inhibitor-1 (PAI-1), (F) total thrombin-activatable fibrinolysis inhibitor (TAFI), and (F) activated TAFI (TAFIa/ai) levels were analyzed according to the manufacturers’ instructions. TAFIa/ai levels were not increased after rTM treatment except for the case #3 and #8. In the case of #8, TAFIa/ai levels at any points were higher than 200 ng/mL, the upper limit of this measurement, however, the absorbance values were increased after rTM treatment from 2.19 to 2.32 on day 1, and from 2.48 to 2.62 on day 2