Table 2 Accuracy of D-dimer interpretation strategies for VTE
Parameter | Conventional strategy | Age-adjusted strategy | Wells-adjusted strategy | YEARS-adjusted strategy |
|---|---|---|---|---|
Negative results | ||||
n/N | 182/368 | 233/368 | 237/368 | 368 |
% (95% CI) | 49.5 (44.2-54.7) | 63.3 (58.2-68.3) | 64.4 (59.3-69.3) | 71.5 (66.6-76.0) |
Sensitivity | ||||
n/N | 16/17 | 13/17 | 11/17 | 10/17 |
% (95% CI) | 94.1 (71.3-99.9) | 76.5 (50.1-93.2) | 64.7 (38.3-85.8) | 58.8 (32.9-81.6) |
Specificity | ||||
n/N | 181/351 | 229/351 | 231/351 | 256/351 |
% (95% CI) | 51.6 (46.2-56.9) | 65.2 (60.0-70.2) | 65.8 (60.6-70.8) | 72.9 (68.0-77.5) |
Negative predictive value | ||||
n/N | 181/182 | 229/233 | 231/237 | 256/263 |
% (95% CI) | 99.5 (97.0-100) | 98.3 (95.7-99.5) | 97.5 (94.6-99.1) | 97.3 (94.6-98.9) |
Negative likelihood ratio | 0.11 | 0.36 | 0.54 | 0.56 |
% (95% CI) | 1.66-2.29 | 0.15-0.85 | 0.28-1.03 | 0.32-1.00 |
Positive likelihood ratio | 1.95 | 2.20 | 1.89 | 2.17 |
% (95% CI) | 0.02-0.76 | 1.63-2.97 | 1.29-2.77 | 1.41-3.35 |