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Fig. 7 | Thrombosis Journal

Fig. 7

From: Tranexamic acid alters the immunophenotype of phagocytes after lower limb surgery

Fig. 7

Effects of TXA on T cell cytokines in orthopaedic surgery. Levels of central T cell cytokines were evaluated with ELISA to better characterise the effects of TXA on the T cell response. The Th1 cytokine IFN-y (A) and the proinflammatory mediator IL-6 (B) were not significantly changed by TXA, while the surgery induced increase in immunosuppressive IL-10 was dampened by TXA at the EOS time point (C). Data represent fold-change from preOP levels and are expressed as mean ± standard error of the mean. Placebo: n = 4, TXA: n = 12–13. *p = 0.05, 2-tailed Student t test. preOP: pre-operative, EOS: end of surgery, POD-1: post-operative day 1, POD-3: post-operative day 3

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