Fig. 1

ADP-induced whole blood aggregometry. The four graphs show ADP-induced platelet inhibition over time following cangrelor bolus infusions of 5 mg (upper left panel, n = 12), 10 mg (upper right panel, n = 12), 20 mg (lower left panel, n = 11) and weight-adapted cangrelor bolus infusion followed by a continuous infusion via IV flow regulator (lower right panel, n = 11). The dashed lines mark the cut-off values for HTPR, MTPR and LTPR. Moderate platelet inhibition levels of 19–46 U (MTPR) are considered to be within the therapeutic window. Data are shown as mean ± standard deviation. (ADP = adenosine diphosphate, MEA = multiple electrode aggregometry, HTPR = high on-treatment platelet reactivity, MTPR = moderate on-treatment platelet reactivity, LTPR = low on-treatment platelet reactivity)