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Fig. 2 | Thrombosis Journal

Fig. 2

From: Advanced pharmacodynamics of cangrelor in healthy volunteers: a dose-finding, open-label, pilot trial

Fig. 2

Platelet function under high shear rates. The four graphs show closure time (measured by the P2Y test of the PFA-100) over time following cangrelor bolus infusions of 5 mg (upper left panel, n = 12), 10 mg (upper right panel, n = 12), 20 mg (lower left panel, n = 11) and weight-adapted cangrelor bolus infusion followed by a continuous infusion via IV flow regulator (lower right panel, n = 11). The dashed line marks the recommended high on-treatment platelet reactivity threshold of 106 s. The PFA-100 does not measure closure times exceeding 301 s, therefore ranges are not shown for a better readability. Data are shown as mean ± standard deviation. (PFA-100 = platelet function analyzer)

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