Fig. 3

Vasodilator-stimulated phosphoprotein phosphorylation (VASP-P) assay. The four graphs show the platelet reactivity index [%] (measured by the VASP-P assay) over time following cangrelor bolus infusions of 5 mg (upper left panel, n = 12), 10 mg (upper right panel, n = 12), 20 mg (lower left panel, n = 11) and weight-adapted cangrelor bolus infusion followed by a continuous infusion via IV flow regulator (lower right panel, n = 11). The dashed line marks the recommended high on-treatment platelet reactivity threshold of PRI 50%. Data are shown as mean ± standard deviation