|
Baseline characteristics
|
Median (IQR)
|
001
|
002
|
003
|
004
|
005
|
006
|
007
|
008
|
009
|
010
|
011
|
012
|
|---|
|
Age - years
|
32 (24.5–40.5)
|
24
|
26
|
29
|
41
|
31
|
51
|
39
|
22
|
21
|
56
|
33
|
35
|
|
Female sex [no.]
|
4 (8 males)
|
0
|
1
|
1
|
1
|
1
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
|
Weight - kilogram
|
69 (59–77)
|
76
|
58
|
60
|
59
|
58
|
70
|
76
|
68
|
77
|
86
|
64
|
91,5
|
|
Ethnicity
|
caucasian = c, black = b, asian = a
|
c
|
c
|
c
|
c
|
c
|
b
|
c
|
a
|
c
|
c
|
c
|
c
|
|
Vital parameters
|
|
RR systolic - mmHg
|
133 (128–146)
|
147
|
107
|
129
|
112
|
136
|
143
|
147
|
128
|
130
|
157
|
140
|
128
|
|
RR diastolic - mmHg
|
79 (73–88.5)
|
80
|
68
|
78
|
72
|
87
|
97
|
95
|
76
|
78
|
89
|
71
|
82
|
|
Heart rate - bpm
|
79 (70–84)
|
80
|
82
|
61
|
53
|
79
|
87
|
69
|
84
|
78
|
76
|
84
|
74
|
|
SpO2 - %
|
98 (97–99)
|
99
|
99
|
100
|
99
|
98
|
95
|
97
|
98
|
98
|
98
|
99
|
97
|
|
Temperature (axilla) – degree celsius (°C)
|
36.0 (35.6–36.1)
|
35,8
|
36,4
|
36
|
36,1
|
36,3
|
35,7
|
35,5
|
35
|
35,5
|
36,0
|
36,0
|
35,9
|
|
PLT count (× 109)a
|
263 (224–281)
|
285
|
291
|
219
|
281
|
280
|
160
|
240
|
247
|
256
|
216
|
270
|
276
|
|
MEA ADP - U
|
68 (59–86)
|
74
|
68
|
96
|
73
|
99
|
39b
|
62
|
58
|
60
|
51
|
90
|
68
|
- PLT platelet, MEA multiple electrode aggregometry, ADP adenosine diphosphate, RR Riva-Rocci ≈ blood pressure, bpm beats per minute, SpO2 peripheral oxygen saturation, IQR interquartile range)
- a Measured at screening visit
- b Healthy subject 006 presented with an initial ADP-induced platelet aggregation of 39 U, which is already within the therapeutic range. ADP-induced platelet aggregation re-increased to 50 U at 60 min after the first bolus infusion of cangrelor and peaked at 64 U just before the following cangrelor bolus infusion. Potential causes of the initial low level of ADP-induced platelet aggregation could involve a false-low measurement or diurnal variation of platelet function. ADP-induced platelet aggregation is also influenced by variations in platelet count, even within the physiological range [44]
