Before propensity score (PS) matching | After propensity score (PS) matching | |||||||
---|---|---|---|---|---|---|---|---|
Overall (N = 722) | BMI < 40 (N = 595) | BMI ≥ 40 (N = 127) | P-value | Overall (N = 254) | BMI < 40 (N = 127) | BMI ≥ 40 (N = 127) | P-value | |
Age (Years), Mean (SD) | 69.9 (11.39) | 70.2 (11.56) | 68.3 (10.46) | 0.0212^ | 68.3 (10.31) | 68.3 (10.20) | 68.3 (10.46) | 0.9806* |
Gender – Male, n (%) | 307 (42.5) | 291 (48.9) | 16 (12.6) | <.0001^^ | 32 (12.6) | 16 (12.6) | 16 (12.6) | 0.9999^^ |
Weight (kg), Mean (SD) | 83.4 (18.90) | 78.1 (14.33) | 108.4 (17.72) | <.0001* | 91.8 (22.59) | 75.2 (12.47) | 108.4 (17.72) | <.0001* |
Body Mass Index (BMI), Median (Q1, Q3) | 32.1 (27.33, 37.86) | 30.5 (26.63, 34.57) | 43.9 (41.71, 47.74) | <.0001* | 39.8 (32.45, 43.86) | 32.5 (27.18, 35.41) | 43.9 (41.71, 47.74) | <.0001* |
Alanine aminotransferase (ALT), Median (Q1, Q3) | 21.0 (14.00, 31.00) | 21.0 (14.00, 31.00) | 19.0 (13.00, 25.00) | 0.0551^ | 19.5 (13.00, 28.00) | 20.0 (13.00, 29.50) | 19.0 (13.00, 25.00) | 0.7210^ |
Aspartate aminotransferase (AST), Median (Q1, Q3) | 22.0 (17.00, 29.00) | 22.0 (17.00, 29.00) | 21.0 (16.00, 28.00) | 0.1182^ | 21.0 (16.00, 28.00) | 21.5 (15.50, 27.00) | 21.0 (16.00, 28.00) | 0.9873^ |
Estimated glomerular filtration rate (eGFR), Median (Q1,Q3) | 83.0 (69.00, 97.00) | 83.0 (69.50, 98.00) | 80.0 (63.00, 92.00) | 0.0229^ | 81.0 (67.00, 94.00) | 83.0 (71.00, 97.00) | 80.0 (63.00, 92.00) | 0.1693* |
Serum creatinine (mmol/l), Median (Q1,Q3) | 73.0 (64.00, 90.00) | 73.5 (64.00, 90.00) | 70.0 (63.00, 85.00) | 0.1956^ | 69.0 (62.00, 82.00) | 69.0 (61.00, 77.00) | 70.0 (63.00, 85.00) | 0.1698^ |
Blood Urea Nitrogen (BUN) (mmol/l), Median (Q1,Q3) | 5.6 (4.30, 7.30) | 5.6 (4.30, 7.20) | 5.7 (4.10, 7.85) | 0.8249^ | 5.3 (4.00, 7.30) | 5.1 (4.00, 6.60) | 5.7 (4.10, 7.85) | 0.1059^ |
Platelets count (10^9/L), Median (Q1, Q3) | 245.0 (203.00, 312.00) | 244.5 (203.00, 309.50) | 255.0 (203.00, 333.00) | 0.2074^ | 261.0 (205.50, 335.00) | 264.0 (209.00, 335.00) | 255.0 (203.00, 333.00) | 0.6115^ |
Hematocrit (Hct), Median (Q1, Q3) | 0.4 (0.35, 0.44) | 0.4 (0.35, 0.44) | 0.4 (0.37, 0.44) | 0.4713^ | 0.4 (0.35, 0.43) | 0.4 (0.35, 0.42) | 0.4 (0.37, 0.44) | 0.0366^ |
Total WBC (10^9/L), Median (Q1, Q3) | 7.8 (6.10, 10.00) | 7.7 (6.10, 10.00) | 8.1 (6.40, 9.94) | 0.4107^ | 8.0 (6.17, 10.05) | 7.9 (6.10, 10.10) | 8.1 (6.40, 9.94) | 0.6404^ |
International normalized ratio (INR), Median (Q1,Q3) | 1.1 (1.04, 1.20) | 1.1 (1.05, 1.22) | 1.1 (1.02, 1.14) | 0.0010^ | 1.1 (1.03, 1.15) | 1.1 (1.04, 1.20) | 1.1 (1.02, 1.14) | 0.2394^ |
Activated partial thromboplastin time (aPTT) (Seconds), Median (Q1, Q3) | 29.9 (27.20, 34.40) | 30.1 (27.45, 34.75) | 28.8 (26.40, 33.10) | 0.0058^ | 29.4 (26.80, 33.90) | 29.8 (27.40, 34.40) | 28.8 (26.40, 33.10) | 0.0453^ |
Total bilirubin (μmol/L), Median (Q1, Q3) | 10.7 (8.10, 14.80) | 10.7 (8.10, 15.00) | 10.7 (7.80, 13.30) | 0.3140^ | 9.8 (7.40, 12.90) | 9.1 (7.10, 12.70) | 10.7 (7.80, 13.30) | 0.0805^ |
Albumin (gm/L), Median (Q1, Q3) | 37.0 (33.00, 40.00) | 37.0 (32.00, 40.00) | 36.0 (33.00, 39.00) | 0.6269^ | 37.0 (33.00, 39.00) | 37.0 (33.00, 40.00) | 36.0 (33.00, 39.00) | 0.2868^ |
Fibrinogen Level (gm/l), Median (Q1,Q3) | 3.9 (2.59, 5.16) | 3.9 (2.29, 5.00) | 5.5 (4.63, 6.18) | 0.0494* | 4.8 (1.64) | 4.2 (1.96) | 5.4 (1.02) | 0.3234* |
D-dimer Level (mg/l), Median (Q1,Q3) | 1.1 (0.47, 2.92) | 1.2 (0.50, 3.08) | 1.0 (0.47, 2.74) | 0.7596^ | 1.1 (0.46, 2.86) | 1.1 (0.42, 3.70) | 1.0 (0.47, 2.74) | 0.9782^ |
Blood sugar level (mmol/L), Median (Q1, Q3) | 7.8 (5.90, 11.40) | 7.7 (5.90, 11.20) | 8.8 (6.10, 11.80) | 0.1628^ | 8.7 (6.00, 12.50) | 8.4 (5.90, 13.20) | 8.8 (6.10, 11.80) | 0.7573^ |
CHA2DS2-VASc Score, Median (Q1, Q3) | 4.0 (3.00, 5.00) | 4.0 (3.00, 5.00) | 4.0 (3.00, 5.00) | 0.5234^ | 4.0 (3.00, 5.00) | 4.0 (3.00, 5.00) | 4.0 (3.00, 5.00) | 0.8711^ |
HAS-BLED Score, Median (Q1, Q3) | 2.0 (1.00, 3.00) | 2.0 (1.00, 3.00) | 2.0 (1.00, 3.00) | 0.0993^ | 2.0 (1.00, 2.00) | 2.0 (1.00, 2.00) | 2.0 (1.00, 3.00) | 0.5930^ |
History of Major Bleeding, n (%) | 4 (0.6) | 3 (0.5) | 1 (0.8) | 0.6963** | 3 (1.2) | 2 (1.6) | 1 (0.8) | 0.5614** |
History of Bariatric Surgery, n (%) | 1 (0.1) | 0 (0.0) | 1 (0.8) | 0.0303** | 1 (0.4) | 0 (0.0) | 1 (0.8) | 0.3164** |
Concomitant Aspirin use, n (%) | 257 (36.0) | 218 (37.0) | 39 (31.5) | 0.2412^^ | 82 (33.1) | 43 (34.7) | 39 (31.5) | 0.5893^^ |
Concomitant Clopidogrel use, n (%) | 93 (13.0) | 82 (13.9) | 11 (8.8) | 0.1223^^ | 29 (11.7) | 18 (14.5) | 11 (8.8) | 0.1598^^ |
Concomitant Ticagrelor use, n (%) | 2 (0.3) | 2 (0.3) | 0 (0.0) | 0.5141** | 0 (0) | 0 (0) | 0 (0) | NA |
Concomitant use of GI prophylaxis (i.e., PPI or H2A), n (%) | 602 (83.4) | 497 (83.5) | 105 (82.7) | 0.81 | 214 (84.3) | 108 (85.0) | 106 (83.4) | 0.7509^^ |
Comorbidity | ||||||||
Aortic Stenosis (AS), n (%) | 32 (4.4) | 27 (4.5) | 5 (3.9) | 0.7652^^ | 10 (3.9) | 5 (3.9) | 5 (3.9) | > 0.9999^^ |
Mitral Stenosis (MS), n (%) | 28 (3.9) | 23 (3.9) | 5 (3.9) | 0.9698** | 10 (3.9) | 5 (3.9) | 5 (3.9) | > 0.9999^^ |
Chronic obstructive pulmonary disease (COPD), n (%) | 42 (5.8) | 30 (5.0) | 12 (9.4) | 0.0541^^ | 22 (8.66) | 10 (7.87) | 12 (9.45) | 0.6555^^ |
Heart Failure, n (%) | 315 (43.6) | 253 (42.5) | 62 (48.8) | 0.1939^^ | 111 (43.7) | 49 (38.6) | 62 (48.8) | 0.1001^^ |
Hypertension, n (%) | 606 (83.9) | 490 (82.4) | 116 (91.3) | 0.0123^^ | 228 (89.7) | 112 (88.2) | 116 (91.3) | 0.4077^^ |
Diabetes mellitus, n (%) | 490 (67.9) | 396 (66.6) | 94 (74.0) | 0.1021^^ | 179 (70.5) | 85 (66.9) | 94 (74.0) | 0.2157^^ |
Dyslipidemia, n (%) | 395 (54.7) | 324 (54.5) | 71 (55.9) | 0.7654^^ | 147 (57.8) | 76 (59.8) | 71 (55.9) | 0.5252^^ |
Hypothyroidism, n (%) | 120 (16.6) | 101 (17.0) | 19 (15.0) | 0.5799^^ | 44 (17.3) | 25 (19.7) | 19 (14.9) | 0.3198^^ |
Hyperthyroidism, n (%) | 9 (1.2) | 8 (1.3) | 1 (0.8) | 0.6074** | 3 (1.18) | 2 (1.57) | 1 (0.79) | 0.5614 |
Ischemic heart disease (IHD), n (%) | 190 (26.3) | 165 (27.7) | 25 (19.7) | 0.0616^^ | 54 (21.3) | 29 (22.8) | 25 (19.7) | 0.5396^^ |
Chronic kidney disease (CKD), n (%) | 85 (11.8) | 72 (12.1) | 13 (10.2) | 0.5539^^ | 27 (10.6) | 14 (11.0) | 13 (10.2) | 0.8387^^ |
Cancer, n (%) | 39 (5.4) | 33 (5.5) | 6 (4.7) | 0.7099^^ | 13 (5.1) | 7 (5.5) | 6 (4.7) | 0.7758^^ |
Venous Thromboembolism, n (%) | 45 (6.2) | 39 (6.6) | 6 (4.7) | 0.4386^^ | 14 (5.5) | 8 (6.3) | 6 (4.7) | 0.5824^^ |
Vascular Disease, n (%) | 9 (1.2) | 6 (1.0) | 3 (2.4) | 0.2119** | 4 (1.6) | 1 (0.8) | 3 (2.4) | 0.3135** |
Liver disease (any type), n (%) | 34 (4.7) | 29 (4.9) | 5 (3.9) | 0.6509^^ | 9 (3.5) | 4 (3.1) | 5 (3.9) | 0.7343** |
Stroke, n (%) | 136 (18.8) | 121 (20.3) | 15 (11.8) | 0.0257^^ | 41 (16.1) | 26 (20.5) | 15 (11.8) | 0.0607^^ |