Table 1 Characteristics patients with acute PE by CCr level
Variable |  ≥ 60 ml/min N = 4559 | 30–60 ml/min N = 1191 |  < 30 ml/min N = 120 | Total N = 5870 | P value |
|---|---|---|---|---|---|
Demographic Features | |||||
 Age, years | 60.0 (49.3, 69.1) | 75.5 (69.2, 80.3) | 78.9 (70.6, 83.5) | 63.6 (52.7, 73.4) |  < .0001 |
 Age > 65 (years) | 1626 (35.7) | 1003 (84.2) | 104 (86.7) | 2733 (46.6) |  < .0001 |
 Age > 80 (years) | 168 (3.7) | 309 (25.9) | 49 (40.8) | 526 (9.0) |  < .0001 |
 Female | 2045 (44.9) | 645 (54.2) | 69 (57.5) | 2759 (47.0) |  < .0001 |
 BMI, kg/m2 | 24.2 (22.2, 26.4) | 22.4 (20.5, 24.8) | 21.5 (19.5, 23.4) | 23.8 (21.7, 26.0) |  < .0001 |
Comorbidities | |||||
 Cardiovascular Disease | 1759 (38.6) | 736 (61.9) | 80 (66.7) | 2575 (43.9) |  < .0001 |
 Respiratory Diseases | 938 (20.6) | 388 (32.7) | 36 (30.0) | 1362 (23.2) |  < .0001 |
 Cancer | 418 (9.2) | 99 (8.4) | 10 (8.3) | 527 (9.0) | 0.6466 |
 Diabetes | 444 (9.8) | 167 (14.1) | 24 (20.0) | 635 (10.9) |  < .0001 |
 Neurological disease | 425 (9.4) | 182 (15.5) | 27 (22.5) | 634 (10.9) |  < .0001 |
 Chronic nephritis | 20 (0.4) | 20 (1.7) | 11 (9.2) | 51 (0.9) |  < .0001 |
 Nephrotic syndrome | 40 (0.9) | 14 (1.2) | 5 (4.2) | 59 (1.0) | 0.0196 |
Vital Signs & Laboratory Tests | |||||
 Pulse ≥ 110 beats/min | 345 (7.6) | 97 (8.3) | 14 (11.8) | 456 (7.8) | 0.2044 |
 Respiratory Rate, times/min | 20.0 (18.0, 22.0) | 20.0 (18.0, 22.0) | 20.0 (19.0, 23.0) | 20.0 (18.0, 22.0) | 0.0013 |
 Systolic blood pressure, mmHg | 125.0 (116.0, 140.0) | 130.0 (118.0, 142.0) | 133.0 (120.0, 147.5) | 127.0 (117.0, 140.0) |  < .0001 |
 Elevated D-dimer | 3574 (87.1) | 951 (88.3) | 97 (92.4) | 4622 (87.4) | 0.1668 |
 Hemoglobin, g/L | 131.0 (117.0, 143.0) | 127.0 (115.0, 139.0) | 115.0 (97.0, 129.0) | 130.0 (116.0, 142.0) |  < .0001 |
 Platelet < 100 × 109/L | 225 (5.0) | 88 (7.5) | 14 (11.8) | 327 (5.6) |  < .0001 |
 PaO2 < 60 mmHg | 699 (17.8) | 263 (25.2) | 25 (24.8) | 987 (19.4) |  < .0001 |
 Creatinine, μmol/L | 66.7 (56.0, 78.5) | 91.0 (77.1, 109.0) | 159.5 (129.0, 212.6) | 71.0 (59.0, 86.0) |  < .0001 |
 BUN, mmol/L | 5.0 (3.9, 6.2) | 6.6 (5.1, 8.4) | 10.2 (7.6, 13.4) | 5.2 (4.0, 6.9) |  < .0001 |
 BUN/Cr | 18.4 (14.3, 23.3) | 17.8 (14.1, 22.3) | 15.7 (11.6, 19.9) | 18.2 (14.2, 23.1) |  < .0001 |
Risk Stratification | |||||
 sPESI ≥ 1 | 4501 (98.7) | 1190 (99.9) | 120 (100.0) | 5811 (99.0) |  < .0001 |
Outcomes | |||||
 All-cause death | 91 (2.0) | 40 (3.4) | 17 (14.2) | 148 (2.5) |  < .0001 |
 PE-related death | 25 (0.5) | 16 (1.3) | 7 (5.8) | 48 (0.8) |  < .0001 |
 Bleeding | 155 (4.8) | 65 (7.5) | 6 (6.9) | 226 (5.4) | 0.0089 |
 Major bleeding | 47 (1.5) | 26 (3.1) | 3 (3.6) | 76 (1.9) | 0.0085 |
 Length of hospital stay (days) | 19.0 (12.0, 30.0) | 18.0 (12.0, 30.0) | 21.0 (13.0, 30.0) | 19.0 (12.0, 30.0) | 0.6522 |