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Table 2 Risk factors of DVT in patients with ARDS caused by COVID-19 and bacterial pneumonia

From: Comparison of deep vein thrombosis risks in acute respiratory distress syndrome caused by COVID-19 and bacterial pneumonia: a retrospective cohort study

Variable

Total ARDS

(N = 240)

Bacterial Pneumonia

(N = 135)

COVID-19

(N = 105)

P for Interaction With COVID-19 Status

Adjusted HR

(95% CI)

P value

Adjusted HR

(95% CI)

P value

Adjusted HR

(95% CI)

P value

Age,

per 10 years

1.143

(0.996, 1.311)

0.056

1.164

(0.935, 1.449)

0.174

1.055

(0.861, 1.292)

0.606

0.644

Serum creatinine, per 10 μmol/L

0.956

(0.925, 0.988)

0.007

0.960

(0.913, 1.010)

0.118

0.989

(0.967, 1.012)

0.335

0.072

Serum procalcitonin,

per 1 ng/L

1.003

(0.978, 1.027)

0.840

1.020

(0.986, 1.055)

0.262

1.358

(0.832, 2.217)

0.221

0.363

CK-MB,

per 1 U/L

0.998

(0.993, 1.002)

0.258

0.992

(0.983, 1.002)

0.114

1.014

(1.005, 1.024)

0.003

0.016

PaO2/FiO2,

per 1 mmHg

0.996

(0.993, 0.999)

0.015

0.998

(0.992, 1.003)

0.433

0.997

(0.993, 1.000)

0.081

0.480

D-dimer

  < 0.5 μg/mL

Reference

 

Reference

 

Reference

  

  ≥ 0.5 μg/mL

2.011

(1.208, 3.347)

0.007

1.526

(0.777, 2.999)

0.220

2.655

(0.945, 7.456)

0.064

0.457

IMV

  No

Reference

 

Reference

 

Reference

  

  Yes

1.687

(1.140, 2.496)

0.009

3.029

(1.541, 5.953)

0.001

0.798

(0.441, 1.443)

0.455

0.372

VTE prophylaxis

  No

Reference

 

Reference

 

Reference

  

  Yes

0.796

(0.539, 1.175)

0.250

0.467

(0.267, 0.816)

0.007

1.367

(0.755, 2.478)

0.303

0.022

  1. Based on univariate test results and prior knowledge, death was used as a competitive risk; Fine and Gray competing risk analysis was performed in the ARDS cohorts. The interactions of ARDS type (COVID-19 status) with age, serum creatinine level, serum procalcitonin level, CK-MB level, PaO2/FiO2, D-dimer level, and IMV, were included in the analysis
  2. Abbreviations: ARDS acute respiratory distress syndrome, CK creatine kinase isoenzyme, CI confidence interval, COVID-19 coronavirus disease 2019, DVT deep venous thrombosis, FiO2 a fraction of inspired oxygen, IMV invasive mechanical ventilation, OR odds ratio, PaO2 partial pressure of arterial oxygen, VTE venous thromboembolism