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Table 2 Risk factors of DVT in patients with ARDS caused by COVID-19 and bacterial pneumonia

From: Comparison of deep vein thrombosis risks in acute respiratory distress syndrome caused by COVID-19 and bacterial pneumonia: a retrospective cohort study

Variable Total ARDS
(N = 240)
Bacterial Pneumonia
(N = 135)
COVID-19
(N = 105)
P for Interaction With COVID-19 Status
Adjusted HR
(95% CI)
P value Adjusted HR
(95% CI)
P value Adjusted HR
(95% CI)
P value
Age,
per 10 years
1.143
(0.996, 1.311)
0.056 1.164
(0.935, 1.449)
0.174 1.055
(0.861, 1.292)
0.606 0.644
Serum creatinine, per 10 μmol/L 0.956
(0.925, 0.988)
0.007 0.960
(0.913, 1.010)
0.118 0.989
(0.967, 1.012)
0.335 0.072
Serum procalcitonin,
per 1 ng/L
1.003
(0.978, 1.027)
0.840 1.020
(0.986, 1.055)
0.262 1.358
(0.832, 2.217)
0.221 0.363
CK-MB,
per 1 U/L
0.998
(0.993, 1.002)
0.258 0.992
(0.983, 1.002)
0.114 1.014
(1.005, 1.024)
0.003 0.016
PaO2/FiO2,
per 1 mmHg
0.996
(0.993, 0.999)
0.015 0.998
(0.992, 1.003)
0.433 0.997
(0.993, 1.000)
0.081 0.480
D-dimer
  < 0.5 μg/mL Reference   Reference   Reference   
  ≥ 0.5 μg/mL 2.011
(1.208, 3.347)
0.007 1.526
(0.777, 2.999)
0.220 2.655
(0.945, 7.456)
0.064 0.457
IMV
  No Reference   Reference   Reference   
  Yes 1.687
(1.140, 2.496)
0.009 3.029
(1.541, 5.953)
0.001 0.798
(0.441, 1.443)
0.455 0.372
VTE prophylaxis
  No Reference   Reference   Reference   
  Yes 0.796
(0.539, 1.175)
0.250 0.467
(0.267, 0.816)
0.007 1.367
(0.755, 2.478)
0.303 0.022
  1. Based on univariate test results and prior knowledge, death was used as a competitive risk; Fine and Gray competing risk analysis was performed in the ARDS cohorts. The interactions of ARDS type (COVID-19 status) with age, serum creatinine level, serum procalcitonin level, CK-MB level, PaO2/FiO2, D-dimer level, and IMV, were included in the analysis
  2. Abbreviations: ARDS acute respiratory distress syndrome, CK creatine kinase isoenzyme, CI confidence interval, COVID-19 coronavirus disease 2019, DVT deep venous thrombosis, FiO2 a fraction of inspired oxygen, IMV invasive mechanical ventilation, OR odds ratio, PaO2 partial pressure of arterial oxygen, VTE venous thromboembolism