Phenprocoumon | ld-DOAC | ld-Apixaban | ld-Dabigatran | ld-Edoxaban | ld-Rivaroxaban | |
---|---|---|---|---|---|---|
n | 20,179 | 21,724 | 10,997 | 1914 | 2255 | 6558 |
Baseline characteristics: mean (SD) | ||||||
Age | 74.81 (10.11) | 79.51 (9.67) | 81.48 (8.70) | 76.5 (10.36) | 79.96 (9.19) | 76.94 (10.34) |
Female persons (%) | 41.70 | 49.77 | 53.19 | 43.78 | 53.48 | 44.50 |
CCI | 3.03 (2.08) | 3.58 (2.15) | 3.77 (2.14) | 3.2 (2.1) | 3.5 (2.18) | 3.39 (2.13) |
CHA2DS2-VASc-Score (without gender) | 3.7 (1.59) | 4.21 (1.56) | 4.41 (1.49) | 4.06 (1.65) | 4.05 (1.53) | 3.98 (1.61) |
Prescriptions in addition to OAC | 9.81 (5.28) | 10.81 (5.55) | 11.13 (5.55) | 9.89 (5.18) | 10.37 (5.46) | 10.7 (5.63) |
Comorbidities: Proportion of patients with … (%) | ||||||
Acute renal impairment | 6.49 | 9.59 | 11.34 | 4.96 | 9.62 | 7.99 |
Moderate chronic renal impairment | 22.56 | 32.57 | 35.37 | 21.06 | 36.72 | 29.80 |
Severe chronic renal impairment | 6.00 | 6.44 | 8.07 | 1.57 | 7.36 | 4.82 |
Renal impairment (total) | 33.80 | 45.59 | 49.65 | 29.83 | 49.53 | 42.04 |
Dementia | 8.66 | 17.90 | 21.14 | 13.06 | 16.54 | 14.33 |
Thrombosis | 3.68 | 4.00 | 3.92 | 2.72 | 3.28 | 4.77 |
Arterial hypertension | 89.55 | 91.25 | 92.37 | 89.92 | 89.76 | 90.29 |
Diabetes | 36.58 | 39.97 | 40.27 | 35.32 | 39.96 | 40.85 |
Smoker | 8.22 | 7.14 | 6.27 | 8.15 | 6.16 | 8.65 |
Alcohol abuse | 3.03 | 3.42 | 3.19 | 3.19 | 3.41 | 3.86 |
Myocardial infarction | 8.80 | 11.84 | 10.78 | 13.48 | 7.80 | 14.53 |
Stroke | 4.20 | 5.61 | 6.29 | 7.84 | 3.99 | 4.36 |
Atherosclerosis | 19.68 | 21.69 | 22.23 | 20.38 | 21.64 | 21.20 |
Cancer | 21.50 | 24.73 | 25.84 | 21.79 | 26.03 | 23.28 |
Liver disease | 18.48 | 18.11 | 17.77 | 17.29 | 20.22 | 18.19 |
Cachexia | 0.69 | 1.95 | 2.31 | 0.84 | 1.86 | 1.69 |
Adiposity | 28.09 | 24.36 | 23.19 | 22.15 | 23.73 | 27.19 |
Orthopaedic implant | 3.49 | 8.83 | 9.04 | 5.22 | 11.49 | 8.63 |
Comedication: Proportion of patients with … (%) | ||||||
Antihypertensive medication | 7.45 | 7.92 | 8.25 | 6.74 | 9.00 | 7.35 |
Heparin | 26.77 | 10.13 | 9.97 | 9.67 | 10.38 | 10.46 |
Diuretics | 54.96 | 59.63 | 64.05 | 48.69 | 57.34 | 56.19 |
Antiarrhythmic med. | 87.76 | 86.97 | 87.59 | 85.16 | 85.68 | 86.92 |
NSAIDs | 32.88 | 32.79 | 31.45 | 34.74 | 30.95 | 35.10 |
Antiplatelet therapy | 26.05 | 36.83 | 36.72 | 36.31 | 30.64 | 39.28 |
Lipid lowering medication | 47.88 | 48.15 | 47.48 | 54.08 | 45.19 | 48.57 |
Anti-ulcer therapy | 47.10 | 53.65 | 55.26 | 49.01 | 49.36 | 53.80 |
Cardiac glycosides | 11.44 | 9.91 | 10.76 | 7.94 | 8.65 | 9.50 |
Oral corticosteroids | 12.74 | 14.51 | 14.45 | 14.37 | 14.01 | 14.84 |
Antipsychotic medication | 4.39 | 9.26 | 10.65 | 7.68 | 8.38 | 7.69 |
Inpatient diagnosis before index date … (%) | ||||||
Thromboembolic event | 5.80 | 11.91 | 14.28 | 20.79 | 7.14 | 6.98 |
Bleeding | 2.45 | 3.05 | 3.58 | 3.08 | 2.08 | 2.47 |
Outpatient diagnosis before index date … (%) | ||||||
Thromboembolic event | 10.32 | 13.97 | 15.26 | 19.64 | 11.13 | 11.13 |
Bleeding (no blood transfusion) | 1.58 | 2.09 | 2.38 | 1.99 | 1.95 | 1.69 |