Table 1 Patient characteristics

Demographics

  Age (years), median (IQR)

66 (56 to 76)

70 (62 to 79)

0.16

  Male, n (%)

49 (60)

14 (64)

0.74

Underlying disease types

  Hematopoietic disorders, n (%)

38 (46)

12 (55)

0.49

  Infectious diseases, n (%)

36 (44)

5 (23)

0.07

  The others, n (%)

8 (10)

5 (23)

0.10

Laboratory tests

  Platelet (× 10⁹/L), median (IQR)

40 (22 to 60)

18.5 (12 to 40)

0.03

  D-dimer (µg/mL), median (IQR)

16.3 (9.6 to 43.2)

16.2 (11 to 111.2)

0.27

  PT-INR, median (IQR)

1.40 (1.13 to 1.55)

1.47 (1.27 to 1.70)

0.22

  Fibrinogen (g/L), median (IQR)

2.9 (1.2 to 4.1)

1.6 (1.2 to 3.0)

0.12

  HMGB1^a (ng/mL), median (IQR)

6.8 (3.1 to 13.6)

16.3 (8.5 to 66.9)

 < 0.001

  Histone H3^a (ng/mL), median (IQR)

2.1 (0.4 to 7.8)

4.8 (2.4 to 31.6)

0.002

  DIC score (point), median (IQR)

5 (5 to 6)

5 (5 to 6)

0.40

  5 points, n (%)

57 (70)

13 (59)

0.35

  6 points, n (%)

18 (22)

7 (32)

0.34

  7 points, n (%)

7 (9)

2 (9)

0.93

  8 points, n (%)

NA

NA

NA

Anti-DIC agents

  rhTM, n (%)

50 (61)

18 (82)

0.07

  Antithrombin, n (%)

18 (22)

8 (36)

0.17