Prognostic value of plasma high mobility group box 1 protein and histone H3 levels in patients with disseminated intravascular coagulation: a multicenter prospective cohort study

Table 3 Comparison of discrimination, calibration, and NRI between DIC scores vs. HMGB1 and histone H3

	DIC scores	HMGB1	p-value*	Histone H3	p-value*
Discrimination
AUC, (95% CI)	0.55 (0.43 to 0.67)	0.74 (0.63 to 0.85)	0.03	0.71 (0.60 to 0.82)	0.07
Calibration
HL test, P-value	0.93	0.49	NA	0.10	NA
Category-free NRI
Overall NRI, (95% CI)		0.45 (0.01 to 0.90)	0.04	0.37 (− 0.05 to 0.78)	0.08
Event NRI		− 0.18		− 0.36
Non-event NRI		0.63		0.73

DIC disseminated intravascular coagulation, HMGB1 high mobility group box-1 protein, AUC area under the receiver operating characteristic curve, HL Hosmer–Lemeshow, NRI net reclassification improvement, NA not applicable
^* p-value is the null hypothesis that each prediction index of the DIC scoring system is equal to that of HMG1 and histone H3

ISSN: 1477-9560