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Table 2 Parameters of thrombin generation and levels of natural coagulation and anti-coagulant factors in the reference, arterial and venous subsample

From: Relationships between coagulation factors and thrombin generation in a general population with arterial and venous disease background

Variable

Group

Reference group (n = 1402)

Mean ± SD

Arterial Disease group (n = 502)

Mean ± SD

p-value

arterial disease vs. reference

Venous Disease group (n = 195)

Mean ± SD

p-value

venous disease vs. reference

Lag Time [min]

4.94 ± 1.03

6.56 ± 3.71

< 0.0001

6.50 ± 3.95

< 0.0001

ETP [nM.min]

1105.0 ± 237.4

1045.0 ± 360.8

0.00056

1048.5 ± 423.3

0.070

Peak Height [nM]

118.37 ± 54.81

113.09 ± 55.36

0.067

113.50 ± 60.32

0.29

Factor II [%]

116.9 ± 17.6

108.7 ± 28.9

< 0.0001

104.8 ± 32.7

< 0.0001

Factor V [%]

116.6 ± 18.5

118.9 ± 19.9

0.024

118.4 ± 22.0

0.29

Factor VII [%]

111.1 ± 21.6

108.3 ± 31.2

0.056

107.2 ± 34.8

0.12

Factor VIII [%]

115.3 ± 33.1

136.3 ± 40.2

< 0.0001

140.1 ± 46.5

< 0.0001

Factor IX [%]

106.3 ± 14.4

110.9 ± 21.7

< 0.0001

107.4 ± 24.3

0.53

Factor X [%]

113.10 ± 19.09

105.59 ± 33.53

< 0.0001

103.87 ± 38.95

0.0013

Factor XI [%]

106.8 ± 18.2

110.2 ± 19.8

0.00090

112.6 ± 19.4

< 0.0001

Factor XII [%]

105.6 ± 24.3

102.1 ± 24.9

0.0071

105.5 ± 24.7

0.98

vWF [%]

103.1 ± 35.5

127.7 ± 45.0

< 0.0001

127.7 ± 48.3

< 0.0001

Protein C [%]

113.3 ± 17.2

111.3 ± 26.1

0.097

110.2 ± 28.3

0.13

Protein S [%]

95.1 ± 16.4

100.3 ± 24.1

< 0.0001

93.4 ± 24.7

0.34

Antithrombin [%]

102.8 ± 9.8

98.1 ± 11.9

< 0.0001

100.8 ± 10.7

0.014

TFPI Activity [U/mL]

1.57 ± 0.53

1.63 ± 0.57

0.040

1.64 ± 0.52

0.084

Fibrinogen [mg/dL]

331 ± 66

395 ± 95

< 0.0001

391 ± 95

< 0.0001

  1. Presented are thrombin generation parameters and coagulation factors in the reference, arterial disease and venous disease subsample
  2. Abbreviations: SD standard deviation, vWF Von Willebrand Factor, TFPI Tissue Factor Pathway Inhibitor