Table 1 Receiver-operating characteristics analyses of the different thromboelastometric tests

Apixaban > 30 ng/mL

TFTEM CT

0.9530

0.02285

< 0.0001

88

95

> 179

Apixaban > 30 ng/mL

ECATEM CT

0.6425

0.05871

0.0207

48

85

< 92

Apixaban > 30 ng/mL

TFTEM/ ECATEM CT-ratio

0.9455

0.02458

< 0.0001

84

95

> 1.988

Apixaban > 30 ng/mL

EXTEM CT

0.8965

0.03687

< 0.001

70

95

> 68

Apixaban > 30 ng/mL

FIBTEM CT

0.7935

0.04646

< 0.0001

68

78

> 66

Apixaban > 30 ng/mL

HEPTEM CT

0.7740

0.06150

0.0004

76

75

> 195

Apixaban > 30 ng/mL

NATEM CT

0.6000

0.06037

0.1044

80

40

> 779

Apixaban > 60 ng/mL

TFTEM CT

0.9605

0.02503

< 0.0001

93

94

> 210

Apixaban > 60 ng/mL

ECATEM CT

0.6343

0.05876

0.0292

55

72

< 95

Apixaban > 60 ng/mL

EXTEM CT

0.9236

0.03171

< 0.0001

83

90

> 68

Apixaban > 60 ng/mL

FIBTEM CT

0.8588

0.04026

< 0.0001

80

78

> 66

Apixaban > 60 ng/mL

HEPTEM CT

0.7975

0.05315

< 0.0001

67

49

> 195

Apixaban > 60 ng/mL

NATEM CT

0.6458

0.05851

0.0179

65

60

> 858

Apixaban > 60 ng/ml

TFTEM/ ECATEM CT-ratio

0.9570

0.02555

< 0.0001

85

98

> 2.460

Edoxaban > 30 ng/mL

TFTEM CT

0.9975

0.002884

< 0.0001

100

98

> 199

Edoxaban > 30 ng/mL

ECATEM CT

0.6520

0.05802

0.0136

52

70

< 96

Edoxaban > 30 ng/mL

TFTEM/ ECATEM CT-ratio

0.9985

0.001759

< 0.0001

96

100

> 2.244

Edoxaban > 30 ng/mL

EXTEM CT

0.9990

0.001691

< 0.0001

98

100

> 73

Edoxaban > 30 ng/mL

FIBTEM CT

0.9738

0.01303

< 0.0001

94

90

> 72

Edoxaban > 30 ng/mL

HEPTEM CT

0.9455

0.02461

< 0.0001

82

95

> 213

Edoxaban > 30 ng/mL

NATEM CT

0.6525

0.05782

0.0133

46

90

> 1041

Edoxaban > 60 ng/mL

TFTEM CT

0.9870

0.007937

< 0.0001

98

92

> 264

Edoxaban > 60 ng/mL

ECATEM CT

0.5710

0.06042

0.2489

80

34

< 101

Edoxaban > 60 ng/mL

EXTEM CT

0.9896

0.008586

< 0.0001

95

100

> 84

Edoxaban > 60 ng/mL

FIBTEM CT

0.9905

0.007477

< 0.0001

95

98

> 81

Edoxaban > 60 ng/mL

HEPTEM CT

0.9358

0.02911

< 0.0001

85

97

> 222

Edoxaban > 60 ng/mL

NATEM CT

0.7330

0.05592

0.0002

55

90

> 1041

Edoxaban > 60 ng/mL

TFTEM/ ECATEM CT-ratio

0.9765

0.01263

< 0.0001

98

90

> 2.719

Rivaroxaban > 30 ng/mL

TFTEM CT

0.9980

0.002176

< 0.0001

98

98

> 198

Rivaroxaban > 30 ng/mL

ECATEM CT

0.6585

0.05850

0.0101

62

73

< 103

Rivaroxaban > 30 ng/mL

TFTEM/ ECATEM CT-ratio

0.9975

0.002879

< 0.0001

98

100

> 2.180

Rivaroxaban > 30 ng/mL

FIBTEM CT

0.9985

0.001892

< 0.0001

98

100

> 86

Rivaroxaban > 30 ng/mL

NATEM CT

0.8125

0.04512

< 0.0001

84

68

> 896

Rivaroxaban > 60 ng/mL

TFTEM CT

0.9850

0.008727

< 0.0001

93

96

> 304

Rivaroxaban > 60 ng/mL

ECATEM CT

0.7060

0.05722

0.0008

73

70

> 101

Rivaroxaban > 60 ng/mL

FIBTEM CT

0.9890

0.007630

< 0.0001

93

98

> 106

Rivaroxaban > 60 ng/mL

NATEM CT

0.8425

0.04153

< 0.0001

78

80

> 953

Rivaroxaban > 60 ng/mL

TFTEM/ ECATEM CT-ratio

0.9770

0.01268

< 0.0001

98

90

> 2.568

Any DXaI > 30 ng/mL

TFTEM CT

0.9828

0.008352

< 0.0001

96

95

> 179

Any DXaI > 30 ng/mL

ECATEM CT

0.5453

0.04771

0.3788

39

78

< 95

Any DXaI > 30 ng/mL

TFTEM/ ECATEM CT-ratio

0.9805

0.008711

< 0.0001

90

100

> 2.180

Any DXaI > 30 ng/mL

FIBTEM CT

0.9219

0.01925

< 0.0001

81

90

> 72

Any DXaI > 30 ng/mL

NATEM CT

0.6883

0.04377

0.0003

52

80

> 948

Any DXaI > 60 ng/mL

TFTEM CT

0.9494

0.01469

< 0.0001

89

86

> 264

Any DXaI > 60 ng/mL

ECATEM CT

0.5214

0.04320

0.6235

25

84

> 107

Any DXaI > 60 ng/mL

TFTEM/ ECATEM CT-ratio

0.9387

0.01728

< 0.0001

90

86

> 2.719

Any DXaI > 60 ng/mL

FIBTEM CT

0.8971

0.02208

< 0.0001

81

86

> 79

Any DXaI > 60 ng/mL

NATEM CT

0.7362

0.03582

< 0.0001

61

81

> 948

Dabigatran > 30 ng/mL

TFTEM CT

0.9460

0.02185

< 0.0001

96

83

> 150

Dabigatran > 30 ng/mL

ECATEM CT

1.0

0.0

< 0.0001

100

100

> 128

Dabigatran > 30 ng/mL

TFTEM/ ECATEM CT-ratio

0.9190

0.02917

< 0.0001

78

100

< 0.9251

Dabigatran > 30 ng/mL

FIBTEM CT

0.9975

0.002520

< 0.0001

98

98

> 78

Dabigatran > 30 ng/mL

NATEM CT

0.9820

0.01001

< 0.0001

96

90

> 1049

Dabigatran > 60 ng/mL

TFTEM CT

0.9578

0.01826

< 0.0001

95

84

> 164

Dabigatran > 60 ng/mL

ECATEM CT

1.0

0.0

< 0.0001

100

100

> 177

Dabigatran > 60 ng/mL

FIBTEM CT

0.9823

0.01004

< 0.0001

95

92

> 97

Dabigatran > 60 ng/mL

NATEM CT

0.9760

0.01212

< 0.0001

93

90

> 1182

Dabigatran > 60 ng/mL

TFTEM/ ECATEM CT-ratio

0.9420

0.02975

< 0.0001

88

100

< 0.8779

Any DOAC > 30 ng/mL

TFTEM CT

0.9736

0.009820

< 0.001

90

95

> 179

Any DOAC > 30 ng/mL

ECATEM CT

0.5910

0.03951

0.0693

26

100

> 123

Any DOAC > 30 ng/mL

FIBTEM CT

0.9408

0.01481

< 0.0001

80

98

> 78

Any DOAC > 30 ng/mL

NATEM CT

0.7618

0.03522

< 0.0001

55

90

> 1041

Any DOAC > 30 ng/ml

TFTEM/ECATEM ratio

0.7556

0.02939

< 0.0001

68

100

> 2.180

Any DOAC > 60 ng/mL

TFTEM CT

0.9200

0.01693

< 0.0001

88

78

> 219

Any DOAC > 60 ng/mL

ECATEM CT

0.5921

0.03689

0.0200

25

100

> 177

Any DOAC > 60 ng/mL

FIBTEM CT

0.8958

0.01974

< 0.0001

86

78

> 79

Any DOAC > 60 ng/mL

NATEM CT

0.7563

0.03090

< 0.0001

62

81

> 1041

Any DOAC > 60 ng/ml

TFTEM/ECATEM ratio

0.7186

0.03370

< 0.0001

68

88

> 2.719