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Table 2 Effects of a 180 mg loading dose followed by 90 mg maintenance dose of Brilique ® versus Ticaloguard ® on ADP aggregation test of healthy volunteers at different time intervals

From: Testing P2Y12 platelet inhibitors generics beyond bioequivalence: a parallel single-blinded randomized trial

Groups

% ADP aggregation

 

Baseline

1 h after LD

3 h after LD

At day 4, reaching Css

12 h after drug stop

A day after drug stop

Brili group (n = 14)

69 (48–81)

3 (0–13)

7.5 (0–87)

8 (1–33)

17.5 (0–36)

23 (0–48)

Tica group

(n = 15)

75 (48–85)

6 (0–80)

4 (0–88)

22 (0–29)

17 (5–35)

31 (10–75)

p-value

0.06

0.067

0.721

0.189

0.844

0.169

  1. Data are presented as median (range)
  2. Abbreviation: Brili Brilique®, Tica Ticaloguard®, ADP Adenosine diphosphate, LD Loading dose, hr Hour, Css Steady state concentration. P: Non-significant by independent-sample Mann–Whitney U test
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Thrombosis Journal

ISSN: 1477-9560

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