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Table 3 Effects of a 180 mg loading dose followed by 90 mg maintenance dose of Brilique® versus Ticaloguard® on % platelet inhibition compared to zero inhibition at baseline of healthy volunteers at different time intervals

From: Testing P2Y12 platelet inhibitors generics beyond bioequivalence: a parallel single-blinded randomized trial

Groups

% Platelet inhibition

 

1 h after LD

3 h after LD

At day 4, reaching Css

12 h after drug stop

A day after drug stop

Brili group (n = 14)

95.4 (72.9–100)

88.6 (-12.9–100)

89.2 (43.1–98.5)

73.4 (39.5–100)

67.3(34.2–100)

Tica group

(n = 15)

87.5 (-2.5–100)

95.2 (-12.8–100)

71.0 (56.2–100)

79.7 (50–92.7)

61.25 (-20.6–86.6)

p-value

0.85

0.911

0.371

0.76

0.315

  1. Data are presented as median (range)
  2. Abbreviation: Brili Brilique®, Tica Ticaloguard®, LD Loading dose, hr Hour, Css Steady state concentration. P: Non-significant by independent-sample Mann–Whitney U test. Negative values indicate resistant cases
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Thrombosis Journal

ISSN: 1477-9560

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