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Table 2 Relevant clinical and laboratory parameters assessed in the course of this case

From: The potential impact of Covid-19 on the capacity of routine laboratory tests to detect heparin-induced thrombocytopenia

Clinical/laboratory parameter

Day 1 of suspected HIT

Day 8 of suspected HIT

Test interpretation

4 T score

6/8

-

0–3 low probability

4–5 intermediate probability

6–8 high probability

HIT-IgG Acustar (U/ml)

10.8

43.2

 < 1.0 U/ml

HIT ELISA IgG (O.D.)

(Immuncor, Waukesha, USA)

1.465

2.902

 < 0.4 negative for anti-PF4 antibodies

0.4–1.0 weak positive for anti-PF4 antibodies

 > 1.0 positive for anti-PF4 antibodies

HIPA (wells + out of 4)

1/4

4/4

 ≤ 1/4 wells negative for HIT

 ≥ 2/4 wells positive for HIT

HIPA interpretation

negative

positive

-

  1. ELISA Enzyme-linked immunosorbent assay, HIPA Heparin-induced platelet activation test, HIT Heparin-induced thrombocytopenia, O.D. Optical density