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Table 1 Characteristics of included studies in the systematic review

From: Anticoagulation control, outcomes, and associated factors in long-term-care patients receiving warfarin in Africa: a systematic review

Author ID

Country

Study design

Study population

Sample size

Follow up time

Mean or Median age in years

Service setting

Indication of warfarin

Salaheldin A, 2019 [32]

Sudan

Retrospective

Private cardiology clinic attendants

21

14 months

Mean: 64, Median: 62

Cardiology Clinic

AF, VHD, DVT, PE, LVT

Karuri et al., 2019 [36]

Kenya

Retrospective

Adult outpatients

406

2 years and 6 months

Mean: 42.7 (SD: 16.9)

Cardiac, hemato-oncology, and clinic

DVT, PE, Prosthetic valves, AF, VHD

Sana et al., 2020 [43]

Tunisia

Prospective

AF patients ≥ 20 years

915

12 months

Mean: 64.27

In- and outpatients setting

AF

Lauren et al., 2019 [35]

Namibia

Retrospective

Adult outpatients

215

12 months

Median: 46

Warfarin Clinic

DVT, PE, AF, CVA, AVR, LVT, DCM, MVR, DVR, Others

Sonuga et al., 2016 [37]

South Africa

Retrospective

Adult patients

136

6 months

Mean: 62 (for male), Median: 66 (for female)

INR Clinic

VHD, mechanical heart valve replacement

Fenta et al., 2017 [23]

Ethiopia

Retrospective

Adults outpatients

360

12 months

Mean: 35.3

Cardiac and hematology clinics

AF, DVT, PE, VHD, MI, HVR, PVR

Semakula et al., 2020 [5]

South Africa and Uganda

Retrospective

Outpatients

229

6 months

Median: 56

Anti-coagulation clinic

VTE, AF, VHD

Prinsloo et al., 2021 [38]

South Africa

Retrospective

Adult patients

191

12 months

Median: 56

INR Clinic

AF, VTE, MPHV, APS, and LVT

Ahmed et al., 2017 [41]

Sudan

Pre-and post- Intervention

Adult patients

135

12 months

Mean: 41.8

Anticoagulation clinic

MVR, DVR, total valve replacement

Botsile et al., 2020 [39]

Botswana

Retrospective

Patients aged ≥ 18 years

142

5 months

Mean: 42

INR Clinic

MHV replacement

Masresha et al., 2021 [31]

Ethiopia

Retrospective

Adult outpatients

202

2 years

Mean: 44.33

Outpatient department

AF, VHD, DVT, and PE

Kizito et al., 2016 [47]

Kenya

Prospective

Adult outpatients

147

NA

Mean: 41

Hemato-oncology and cardiothoracic clinics

Heart disease, VTE, HVR

Yimer et al., 2021[40]

Ethiopia

Retrospective

Adult outpatients

300

2 years

Mean: 56.4

Anticoagulation Clinic

AF

Sadhabiriss and Brown, 2021 [33]

South Africa

Retrospective

Adult outpatients

263

1 year

Mean age for AF patients: 64.68, mean age for PHV patients:41.83

Outpatient adult medical department

non-valvular AF, PHV, venous thrombosis or embolism, arterial or left ventricle thrombus, valvular AF, HF

Ntlokotsi et al., 2018 [28]

South Africa

Retrospective

Adult patients

95

19 years

Mean 39.7 (SD:18)

Academic hospital

HVR

Rejeb et al., 2019 [29]

Tunisia

Retrospective

Adult patients

200

3 years

Mean: 58.8 ± 12

Cardiac clinic

AF

Mwita et al., 2017 [30]

Botswana

Retrospective

Adult patients

410

2 years

Median: 46(35–58 IQR)

Outpatient medical clinic

Mechanical valves, DVT, AF, intracardiac thrombosis, pulmonary hypertension

Ebrahim et al., 2018 [7]

South Africa

Retrospective

Adult out patients

363

6 years

Median: 55(IQR 44—64)

Warfarin anticoagulation Clinic

AF, VHD, PE VTE, SLE, hypercoagulable states

  1. AF Atrial fibrillation, VHD Valvular heart disease, DVT Deep vein thrombosis deep, PE Pulmonary embolism, CVA Cerebrovascular accident, AVR Atrial valve replacement, LVT Left ventricular thrombus, DCM Dilated cardiomyopathy, DVR Double valve replacement, MVR Mitral valve replacement, MI Myocardial infarction, SLE Systemic lupus erythematosus, HF Heart failure, APS Antiphospholipid syndrome, MHV Mechanical heart valve, HVR Heart valve replacement, MPHV Mechanical prosthetic heart valve, IQR Interquartile range, SD Standard deviation, INR International normalized ratio