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Table 2 Incidence and characteristics of TEEs in ROS1 rearranged NSCLC

From: The association between ROS1 rearrangement and risk of thromboembolic events in patients with advanced non-small cell lung cancer: a multicenter study in China

Characteristics

Number of patients (%)

Total

11 (11/47, 23.4%)

Type of thromboembolic disease

 Venous

9 (81)

 Arterial

0 (0)

 Both venous and arterial

2 (19)

Patients’ situation

 Ambulatory

5 (45)

 Hospitalized

6 (55)

Time of occurrence

 Before starting treatment

7 (63)

 During treatment

4 (37)

Situation of occurrence of TEEs

 Symptomatic

10 (91)

 Incidental

1 (9)

Time of occurrence according to the clinical situation of the disease

 Untreated

7 (63)

 During platinum-based chemotherapy

2 (28)

 During immune checkpoint therapy

1 (9)

 During ROS1 TKIs treatment

1 (9)

Time of occurrence according to the clinical situation of the disease

 Untreated

7 (63)

 Partial response

0 (0)

 Stable disease

2 (18)

 Progressive disease

2 (18)

Location of TEEs

 Only VTE

  a) Only deep vein thrombosis (DVT)

3 (27)

   Lower extremity DVT

2 (67)

   Upper extremity DVT

1 (33)

   Lower extremity and upper extremity DVT

0 (0)

  b) Only pulmonary embolism (PE)

1 (9)

  c) DVT and PE combined

5 (45)

   Lower extremity DVT and PE

3 (60)

   Upper extremity DVT and PE

1 (20)

   Lower extremity, upper extremity DVT and PE

1 (20)

 Both ATE and VTE

2 (28)

  a) Stroke and DVT

1 (50)

  b) Stroke and PE

1 (50)

Recurrent TEEs

 Yes

5 (45)

  under therapeutic anticoagulation

5 (100)

  not under therapeutic anticoagulation

0 (0)

 No

6 (55)

First-line anti-tumor treatment in patients with TEEs recurrence

 During chemotherapy

3 (3/4, 75%)

 During ROS1 TKIs treatment

2 (2/6, 33%)

Anticoagulation therapy

 Low molecular weight heparin

8 (73)

 Novel oral anticoagulant

3 (27)

  1. Abbreviation: TEEs Thromboembolic events, VTE Venous thromboembolism, ATE Arterial thromboembolism, DVT Deep vein thrombosis, PE Pulmonary embolism