Table 1 Baseline clinical, angiographic and medication according to Lp(a) categories
All patients (n=4,469) | Lp(a) categories(mg/dl) | p value | |||
|---|---|---|---|---|---|
<10 (n=1,402) | 10-30 (n=1,458) | ≥30 (n=1,609) | |||
n=8,550 | n=950 | n=3,714 | n=3,886 | ||
Age, yrs | 59.51±10.27 | 59.15±10.22 | 59.30±10.42 | 60.03±10.16 | 0.041 |
Sex, male(%) | 3577(80.0) | 1163(83.0) | 1166(80.0) | 1248(77.6) | 0.001 |
BMI, kg/m2 | 25.98±3.11 | 26.15±3.10 | 26.00±3.12 | 25.83±3.08 | 0.018 |
Risk factors | |||||
Hypertension | 3034(67.9) | 954(68.0) | 975(66.9) | 1105(68.7) | 0.559 |
Hypercholesterolemia | 3202(71.6) | 1024(73.0) | 1042(71.5) | 1136(70.6) | 0.329 |
Diabetes mellitus | 1507(33.7) | 499(35.6) | 468(32.1) | 540(33.6) | 0.140 |
Current smoker | 2722(60.9) | 886(63.2) | 906(62.1) | 930(57.8) | 0.005 |
Family history of CAD | 1114(24.9) | 335(23.9) | 349(23.9) | 430(26.7) | 0.189 |
COPD | 117(2.6) | 29(2.1) | 38(2.6) | 50(3.1) | 0.205 |
Laboratory findings | |||||
HbA1c,% | 6.30(5.90-7.20) | 6.30(5.90-7.20) | 6.30(5.90-7.10) | 6.30(5.90-7.20) | 0.277 |
Glucose, mmol/L | 6.32±2.26 | 6.39±2.23 | 6.30±2.37 | 6.28±2.18 | 0.324 |
LVEF, % | 61.15±8.15 | 61.77±7.88 | 60.80±8.29 | 60.93±8.23 | 0.003 |
Hs-CRP, mg/L | 1.52(0.76-3.55) | 1.36(0.73-2.83) | 1.58(0.74-3.92) | 1.69(0.82-4.04) | < 0.001 |
eGFR, ml/min | 89.64±16.02 | 90.22±15.51 | 89.49±16.61 | 89.28±15.89 | 0.248 |
HDL-C, mmoL/L | 1.02±0.28 | 1.01±0.28 | 1.01±0.27 | 1.05±0.28 | < 0.001 |
LDL-C, mmoL/L | 2.41±0.89 | 2.25±0.84 | 2.37±0.88 | 2.57±0.91 | < 0.001 |
TG, mmoL/L | 1.75±1.03 | 1.94±1.29 | 1.70±0.96 | 1.61±0.78 | < 0.001 |
TC, mmoL/L | 4.08±1.05 | 3.96±1.03 | 4.02±1.04 | 4.23±1.06 | < 0.001 |
Lp(a), mg/dl | 18.93(7.90-43.03) | 5.06(3.13-7.43) | 17.36(13.08-23.14) | 55.69(40.18-79.75) | < 0.001 |
Presentation | 0.045 | ||||
ACS | 2284(51.1) | 702(50.1) | 784(53.8) | 798(49.6) | |
Stable angina | 2185(48.9) | 700(49.9) | 674(46.2) | 811(50.4) | |
Left main involvement | 126(2.8) | 36(2.6) | 37(2.5) | 53(3.3) | 0.355 |
Mean SYNTAX score | 11.46±8.54 | 11.17±8.37 | 11.48±8.55 | 11.69±8.68 | 0.259 |
Medication at discharge | |||||
aspirin | 4407(98.6) | 1384(98.7) | 1436(98.5) | 1587(98.6) | 0.873 |
clopidogrel | 4397(98.4) | 1379(98.4) | 1439(98.7) | 1579(98.1) | 0.465 |
ACEI/ARB | 2561(57.3) | 803(57.3) | 828(56.8) | 930(57.8) | 0.852 |
Statin | 4256(95.2) | 1334(95.1) | 1386(95.1) | 1586(95.5) | 0.859 |
β-blocker | 4071(91.1) | 1260(89.9) | 1327(91.0) | 1484(92.2) | 0.076 |
CCB | 2121(47.5) | 668(47.6) | 660(45.3) | 793(49.3) | 0.083 |