Table 2 Association of Lp(a) levels with recurrent cardiovacular outcomes in patients with prior CVEs during 5-year follow-up
Endpoints | Events, n/total no.(%) | Crude HR (95% CI) | Crude p-value | Adjusted HR (95% CI) | Adjusted p-value |
|---|---|---|---|---|---|
MACCE | |||||
Log-Lp(a) | — | 1.140 (1.012–1.285) | 0.031 | 1.140 (1.006–1.292) | 0.040 |
Lp(a) < 10 | 310/1402 (22.1%) | 1.00 (reference) | — | 1.00 (reference) | — |
10 ≤ Lp(a) < 30 | 327/1458 (22.4%) | 1.012 (0.866–1.182) | 0.884 | 1.029 (0.878–1.207) | 0.720 |
Lp(a) ≥ 30 | 441/1609 (27.4%) | 1.239 (1.072–1.433) | 0.004 | 1.240 (1.065–1.443) | 0.006 |
All-cause daeth | |||||
Log-Lp(a) | — | 1.506 (1.132–2.002) | 0.005 | 1.386 (1.026–1.872) | 0.033 |
Lp(a) < 10 | 54/1402 (3.9%) | 1.00 (reference) | — | 1.00 (reference) | — |
10 ≤ Lp(a) < 30 | 53/1458 (3.6%) | 0.942 (0.645–1.376) | 0.757 | 0.891 (0.605–1.312) | 0.559 |
Lp(a) ≥ 30 | 99/1609 (6.2%) | 1.597 (1.146–2.225) | 0.006 | 1.445 (1.023–2.042) | 0.037 |
Cardiac death | |||||
Log-Lp(a) | — | 1.776 (1.236–2.552) | 0.002 | 1.591 (1.087–2.330) | 0.017 |
Lp(a) < 10 | 31/1402 (2.2%) | 1.00 (reference) | — | 1.00 (reference) | — |
10 ≤ Lp(a) < 30 | 34/1458 (2.3%) | 1.053 (0.647–1.713) | 0.836 | 1.001 (0.609–1.646) | 0.996 |
Lp(a) ≥ 30 | 69/1609 (4.3%) | 1.939 (1.269–2.962) | 0.002 | 1.724 (1.108–2.681) | 0.016 |
Myocardial infarction | |||||
Log-Lp(a) | — | 1.122 (0.894–1.409) | 0.321 | 1.138 (0.897–1.445) | 0.287 |
Lp(a) < 10 | 86/1402 (6.1%) | 1.00 (reference) | — | 1.00 (reference) | — |
10 ≤ Lp(a) < 30 | 94/1458 (6.4%) | 1.048 (0.782–1.404) | 0.752 | 1.096 (0.812–1.479) | 0.548 |
Lp(a) ≥ 30 | 115/1609 (7.1%) | 1.165 (0.881–1.540) | 0.285 | 1.190 (0.887–1.595) | 0.245 |
Stroke | |||||
Log-Lp(a) | — | 0.875 (0.661–1.159) | 0.352 | 0.843 (0.627–1.133) | 0.257 |
Lp(a) < 10 | 62/1042 (4.4%) | 1.00 (reference) | — | 1.00 (reference) | — |
10 ≤ Lp(a) < 30 | 45/1458 (3.1%) | 0.696 (0.474–1.022) | 0.064 | 0.715 (0.484–1.056) | 0.092 |
Lp(a) ≥ 30 | 72/1609 (4.5%) | 1.012 (0.720–1.421) | 0.947 | 0.965 (0.676–1.379) | 0.847 |
Revascularization | |||||
Log-Lp(a) | — | 1.116 (0.960–1.298) | 0.152 | 1.155 (0.986–1.353) | 0.074 |
Lp(a) < 10 | 192/1402 (13.7%) | 1.00 (reference) | — | 1.00 (reference) | — |
10 ≤ Lp(a) < 30 | 218/1458 (15.0%) | 1.089 (0.897–1.322) | 0.390 | 1.126 (0.923–1.374) | 0.241 |
Lp(a) ≥ 30 | 262/1609 (16.3%) | 1.189 (0.987–1.432) | 0.069 | 1.241 (1.021–1.508) | 0.030 |