Table 1 Baseline characteristics

Age, years, median (range, mean)

78.5

(66–89, 78.2)

Sex, male, n (%)

11

(78.5)

CKD (eGFR < 60), n (%)

12

(85.7)

Hemodialysis^a, n (%)

6

(42.8)

Liver failure^b, n

1

JMHW DIC score, median (range, mean)

8.0

(4–11, 7.7)

Platelet count (×10⁹/L), median (range, normal range)

64

(25–97, 158–348)

FDP (μg/mL), median (range, normal range)

100

(19–270, < 10)

D-dimer (μg/mL), median (range, normal range)

44.3

(13.4–93.7, < 1.0)

FDP/D-dimer, median (range)

2.3

(1.2–4.2)

Fibrinogen (g/L), median (range, normal range)

1.4

(0.56–2.94, 2.0–4.0)

PT ratio, median (range)

1.15

(1.02–1.55)

ATIII (%), median (range, normal range)

78

(56–101, 80–120)

TAT (ng/mL), median (range, normal range)

45.9

(10.9–97.5, 0–4.0)

PIC (μg/mL), median (range, normal range)

5.0

(2.1–10.9, 0–0.8)

Bleeding event (overlap included), n

14

　Difficult hemostasis

10

 　after hemodialysis

5

 　after cardiac catheterization

1

 　after central venous catheter insertion

1

 　during or after surgery

2

 　after blood test

1

 　after thoracic drainage

1

 　after tooth extraction

1

 Subcutaneous hemorrhage

2

 Bloody sputum

2

Aortic treatment prior to TXA, n

13

Number of  aortic treatments prior to TXA, median (range)

2.0

(0–4)

EVAR, n

9

　Days from the most recent treatment, median (range)

1192

(4–5410)

Open aortic aneurysm repair, n

7

　Days from the most recent treatment, median (range)

678

(3-3088)

Transcatheter aortic valve implantation, n

1

　Days from the most recent treatment

88

Transfusion 30 days prior to TXA, n

4

 RBC

4

 FFP

3

 Fibrinogen

2

 PC

2