Table 5 ROC curve analyses for combined ROTEM parameters to identify the coagulation pattern of patients with chronic liver disease and healthy controls

Healthy Controls (CON) vs. Liver Disease Patients (AD + ACLF)

 EXTEM TT20 + INTEM CFT

0.944

0.884–1.000

 < 0.001

0.254

96%

72%

83%

94%

 EXTEM TT20 + EXTEM LI60

0.913

0.827–0.998

 < 0.001

0.319

90

66

79

82

 INTEM CFT + EXTEM LI60

0.927

0.852–1.00

 < 0.001

0.329

90

89

87

85

 EXTEM TT20 + INTEM CFT + EXTEM LI60

0.943

0.876–1.00

 < 0.001

0.678

83

100

100

81

 EXTEM TT20 – EXTEM A5

0.902

0.812–0.991

 < 0.001

106

86

81

87

81

 EXTEM TT20 / EXTEM A5

0.896

0.825–0.987

 < 0.001

4.11

80

100

100

78

 EXTEM TT20 / (EXTEM A5 x EXTEM ML)

0.881

0.775–0.987

 < 0.001

0.780

80

85

87

78

 INTEM CFT – INTEM A5

0.929

0.853–1.000

 < 0.001

45.5

90

85

90

86

 INTEM CFT / INTEM A5

0.929

0.855–1.000

 < 0.001

2.571

80

95

96

77

 INTEM CFT – 10 × INTEM TPI

0.926

0.850–1.000

 < 0.001

67.6

90

85

87

85

 INTEM CFT / INTEM TPI

0.925

0.849–1.000

 < 0.001

50.1

90

81

87

85

 EXTEM TT20 + EXTEM ML-ratio

0.929

0.852–1.000

 < 0.001

0.571

80

90

91

79

 EXTEM TT20 x EXTEM ML-ratio

0.778

0.639–0.918

0.001

53.21

80

58

94

67

 INTEM CFT – INTEM ΔCFT

0.895

0.802–0.988

 < 0.001

87.5

86

85

90

82

 INTEM CFT / EXTEM LI60-ratio

0.948

0.893–1.000

 < 0.001

89

90

85

90

82

 INTEM CFT / EXTEM A5 x EXTEM LI60-ratio

0.947

0.885–1.000

 < 0.001

2

90

85

87

89

 INTEM CFT + EXTEM ML-ratio

0.947

0.887–1.000

 < 0.001

0.587

80

95

95

80

 INTEM CFT x EXTEM ML-ratio

0.919

0.841–0.998

 < 0.001

97.39

80

90

100

63

 INTEM CFT-ratio + EXTEM LI60-ratio

0.879

0.779–0.979

 < 0.001

0.711

80

95

96

77

 INTEM CFT-ratio x EXTEM LI60-ratio

0.170

0.045–0.295

 < 0.001

0.662

80

0.04

56

17

 1 / (INTEM CFT-ratio + EXTEM LI60-ratio)

0.121

0.021–0.221

 < 0.001

1.211

43

0.04

39

6

 1 / (INTEM CFT-ratio x EXTEM LI60-ratio)

0.838

0.720–0.956

 < 0.001

0.973

80

85

59

41

AD vs. ACLF

 INTEM maxV-t – EXTEM ML

0.745

0.555–0.935

0.031

219

80

65

53

87

 INTEM maxV-t / EXTEM ML

0.744

0.508–0.981

0.060

49

85

58

43

92

 INTEM maxV-t + EXTEM LI60

0.81

0.636–0.984

0.006

0.324

80

70

57

87

 INTEM maxV-t x EXTEM LI60

0.750

0.564–0.936

0.028

21,481

80

65

53

87

 INTEM maxV-t – INTEM ΔCFT

0.713

0.531–0.894

0.062

191

90

55

37

83