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Table 2 Laboratory tests of patients in different prophylaxis measures

From: Modern thromboprophylaxis protocol based on guidelines applied in a respiratory intensive care unit: a single-center prospective cohort study

 

Overall (N = 884)

Mechanical prophylaxis group (N = 93)

Pharmacological prophylaxis group (N = 387)

Pharmacological combined mechanical prophylaxis group (N = 404)

P-value

Leukocyte (×109/L) (IQR)

10.4 (6.7, 14.5)

10.4 (5.9, 14.5)

10.1 (6.7, 15.1)

10.7 (6.9, 14.3)

0.811

Hemoglobin (g/L) (IQR)

109 (90, 128)

94 (73, 114)*

111 (95, 129)

109 (90, 129)

< 0.001

Platelet (×109/L) (IQR)

172 (118, 248)

144 (70, 225)*

175 (125, 248)

174 (120, 253)

0.006

D-Dimer (ng/ml) (IQR)

5.0 (1.8,35.2)

4.1 (1.6,35.2)

14.3 (2.3, 25.6)*

3.9 (1.7, 10.7)

< 0.001

Prothrombin time (s) (IQR)

12.9 (11.8, 14.2)

13.0 (11.7, 14.7)

12.4 (11.6, 13.8)*

13.2 (12.1, 14.4)

< 0.001

Fibrinogen (mg/dl) (IQR)

398.0 (279.1, 524.5)

392.9 (268.8, 537.2)

413.5 (392.2, 549.2)

415.5 (294.6, 587.1)

< 0.001

APTT (s) (IQR)

30.9 (25.7, 37.5)

31.0 (25.3, 39.5)

32.1 (27.1, 39.1)†

29.5 (24.9, 35.5)†

< 0.001

AST (U/L) (IQR)

37 (23, 66)

35 (20, 54)

36.0 (24,65)

39 (25,69)

0.080

ALT (U/L) (IQR)

25 (15, 46)

22 (13, 40)

24 (15,42)

28 (16,53)

0.034

Albumin (g/L) (IQR)

29.0 (25.4, 32.5)

28.6 (24.1, 32.5)

28.1 (24.9, 31.8)†

29.7 (26.5, 33.0)†

0.001

Total bilirubin (μmol/L) (IQR)

11.5 (8.2, 17.0)

10.6 (8.2, 19.6)

11.4 (8.2, 15.9)

11.6 (8.4, 17.8)

0.578

Direct bilirubin (μmol/L) (IQR)

5.3 (3.4, 8.6)

5.0 (3.4, 8.5)

4.9 (3.2, 7.6)†

5.7 (3.4, 9.5)†

0.048

Creatinine (μmol/L) (IQR)

73.5 (51.3, 119.6)

83.7 (57.4, 173.9)

74.4 (51.6, 116.7)

69.8 (50.3, 120.4)

0.058

BUN (mmol/L) (IQR)

8.1 (5.6, 13.4)

10.6 (6.8, 16.1)*

8.0 (5.3, 13.4)

7.8 (5.6, 12.4)

0.005

ESR (mm/h) (IQR)

23.0 (10.0, 40.0)

18.5 (5.5, 32.0)¶

20.0 (10.0, 35.0)

28.0 (11.0, 43.5)¶

0.009

C-reactive protein (mg/L) (IQR)

9.6 (3.0, 16.5)

7.9 (2.7, 16.2)

8.8 (2.2, 14.7)†

10.8 (4.6, 19.4)†

< 0.001

  1. *P value for the difference between this group and the other two groups was less than 0.0167
  2. †P value for the difference between the pharmacological prophylaxis group and the pharmacological combined mechanical prophylaxis group was less than 0.0167
  3. ¶P value for the difference between the mechanical prophylaxis group and the pharmacological combined mechanical prophylaxis group was less than 0.0167
  4. APTT activated partial thromboplastin time, AST aspartate aminotransferase, ALT glutamic-pyruvic transaminase, BUN blood urea nitrogen, ESR erythrocyte sedimentation rate