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Table 4 Outcomes for different prophylaxis

From: Modern thromboprophylaxis protocol based on guidelines applied in a respiratory intensive care unit: a single-center prospective cohort study

 

Overall (N = 884)

Mechanical prophylaxis group (N = 93)

Pharmacological prophylaxis group (N = 387)

Pharmacological combined mechanical prophylaxis group (N = 404)

P value

VTE, n (%)

126 (14.3)

13 (14.0)

47 (12.1)

66 (16.3)

0.240

PTE, n (%)

1 (0.1)

0 (0)

1 (0.3)

0 (0.0)

–

DVT, n (%)

125 (14.1)

13 (14.0)

46 (11.9)

66 (16.3)

0.201

Proximal DVT, n (%)

18 (2.0)

1 (1.1)

6 (1.6)

11 (2.7)

0.452

Proximal DVT alone, n (%)

9 (1.0)

1 (1.1)

3 (0.8)

5 (1.2)

–

Proximal and distal DVT, n (%)

9 (1.0)

0 (0)

3 (0.8)

6 (1.5)

–

IDDVT, n (%)

107 (12.1)

12 (12.9)

40 (10.3)

55 (13.6)

0.369

Bleeding events, n (%)

143 (16.2)

13 (14.0)

67 (17.3)

63 (15.6)

0.683

Major bleeding events, n (%)

83 (9.4)

6 (6.5)

38 (9.8)

39 (9.7)

0.596

Anticoagulant-related thrombocytopenia, n (%)

5 (0.6)

0 (0.0)

4 (1.0)

1 (0.2)

0.331

Mortality during RICU hospitalization, n (%)

256 (29.0)

22 (23.7)

124 (32.0)

110 (27.2)

0.167

LOS in RICU (days, IQR)

12 (7, 20)

10 (6, 15)

10.0 (6, 19)

14.0 (9, 25)*

< 0.001

  1. *P values for difference between this group and the other two groups were less than 0.0167
  2. LOS, length of stay; RICU, respiratory intensive care unit; VTE, venous thromboembolism; PTE, pulmonary thromboembolism; DVT, deep vein thrombosis; IDDVT, isolated distal deep vein thrombosis