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Table 1 Baseline characteristics

From: Inadequate response to antiplatelet therapy in patients with peripheral artery disease: a prospective cohort study

 

Total cohort (n = 246)

Event group (n = 26)

No event group (n = 220)

P-value

Mean ± SD / Median (IQR) / n (%)

Mean ± SD / Median (IQR) / n (%)

Mean ± SD / Median (IQR) / n (%)

 

Age (years)

68.7 ± 9.2

71.5 ± 7.9

68.3 ± 9.3

0.093

Male gender

141 (57.3)

17 (65.4)

124 (56.4)

0.379

Newly diagnosed PAD patient upon inclusion

17 (6.9)

2 (7.7)

15 (6.8)

0.868

Chronic PAD patient upon inclusion

229 (93.1)

24 (92.3)

205 (93.2)

0.868

Time between diagnosis and inclusion (months)

33 (8–101)

81 (19–121)

26 (7–89)

0.028*

Intermittent claudication

207 (84.1)

22 (84.6)

185 (84.1)

0.945

Chronic limb ischemia

39 (15.9)

4 (15.4)

35 (15.9)

0.945

History of myocardial infarction

72 (29.3)

14 (53.8)

58 (26.8)

0.004*

History of stroke

37 (15)

10 (38.5)

27 (12.3)

0.001*

Current smoking

94 (38.2)

11 (42.3)

83 (37.7)

0.649

Pack years

29 (15–40)

33 (18–50)

29 (15–40)

0.175

BMI (kg/m2)

26.4 ± 4.41

27.4 ± 5.9

26.3 ± 4.2

0.390

DM2

67 (27.2)

10 (38.5)

57 (25.9)

0.174

HbA1c (mmol/mol)

43 (37–51)

43 (37–53)

43 (37–50)

0.752

Creatinine (μmol/L)

85 (72–104)

101 (77–145)

83 (71–101)

0.006*

eGFR (ml/min/1.73 m2)

71 (58–83)

59 (42–80)

72 (59–84)

0.022*

Haemoglobin (mmol/L)

8.66 ± 0.97

8.3 ± 1.1

8.7 ± 0.95

0.026*

Haematocrit (L/L)

0.42 ± 0.04

0.4 ± 0.04

0.42 ± 0.04

0.027*

Thrombocytes (×  103 /mm3)

272 ± 87

277 ± 82

271 ± 88

0.714

Leukocytes (×  109/L)

7.89 ± 2.2

8.44 ± 3.1

7.83 ± 2

0.342

Neutrophils (%)

62.2 ± 8.2

64 ± 7.5

62 ± 8.2

0.228

Lymphocytes (%)

25.8 ± 6.8

24.1 ± 6.5

26 ± 6.9

0.168

Eosinophils (%)

2 (1–3)

2 (2–3)

2 (1–3)

0.254

Basophils (%)

1 (1–1)

1 (1–1)

1 (1–1)

0.544

Monocytes (%)

8.83 ± 2.4

8.8 ± 3.2

8.8 ± 2.3

0.901

NLR

2.4 (1.9–3.1)

2.5 (2–3.4)

2.4 (1.9–3.1)

0.288

ABI at diagnosis

   

0.156

> 1.30 (incompressible)

17 (6.9)

0 (0)

17 (7.7)

 

0.91–1.30

0 (0)

0 (0)

0 (0)

 

0.70–0.90

109 (44.3)

9 (34.6)

100 (45.5)

 

0.40–0.69

99 (40.2)

16 (61.5)

83 (37.7)

 

< 0.40

21 (8.5)

1 (3.8)

20 (9.1)

 
  1. Baseline characteristics for the whole cohort and distribution between patients with and without cardiovascular events and mortality during follow-up. Significance was reached when P < 0.05 (*), significant values are in bold. PAD peripheral artery disease, BMI body mass index, DM2 diabetes mellitus type 2, HbA1c haemoglobin A1c, eGFR estimated glomerular filtration rate, NLR neutrophil lymphocyte ratio, ABI ankle-brachial index, SD standard deviation, IQR interquartile range