Table 3 Univariate and multivariate Cox regression analysis of prognostic variables affecting mortality

Age

0.99 (0.97, 1.01)

Sex, male vs. female

0.92 (0.63, 1.36)

BMI, Obese vs. Normal

1.10 (0.63, 1.92)

Smoker, Yes vs. No

0.78 (0.55, 1.10)

HTN, Yes vs. No

0.83 (0.55, 1.24)

DM, Yes vs. No

1.71 (1.07, 2.73)

1.79 (1.09, 2.97)

CVD, Yes vs. No

1.15 (0.77, 1.71)

Histology, Adenocarcinoma vs. Others

0.61 (0.34, 1.10)

Sites of cancer

 Cardia or fundus

Ref

Ref

 Corpus

1.47 (0.93, 2.32)

1.11 (0.67, 1.82)

 Antrum or pylorus

1.28 (0.80, 2.06)

1.15 (0.69, 1.93)

 Multiple sites

3.38 (1.68, 6.79)

2.89 (1.38, 6.02)

Stages, IV stage vs. Others

3.22 (2.27, 4.55)

2.31 (1.54, 3.46)

Treatment

 Chemotherapy only

Ref

 Combined surgery

0.36 (0.24, 0.52)

 Combined radiation

1.00 (0.48, 2.08)

 Combined surgery and radiation

0.27 (0.10, 0.76)

CVC, Yes vs. No

1.26 (0.90, 1.77)

Targeted drug, Yes vs. No

2.08 (1.42, 3.06)

PD-1, Yes vs. No

2.51 (1.31, 4.82)

3.23 (1.62, 6.42)

Disease status at the time of VTE diagnosis

 During 3-wk operative period

Ref

Ref

 During four cycles chemotherapy

2.21 (1.24, 3.93)

2.32 (1.21, 4.46)

 During both period

1.69 (0.65, 4.37)

1.92 (0.71, 5.18)

 Neither

1.44 (0.82, 2.52)

2.04 (1.00, 4.17)

Sites of VTE

 DVT

Ref

 SVT

1.96 (1.31, 2.91)

 PE

1.18 (0.61, 2.29)

 Catheter-related thrombosis

0.76 (0.43, 1.35)

Time to VTE diagnosis

0.98 (0.95, 1.00)

0.95 (0.92, 0.99)

Antithrombotic therapy

 LMWH

Ref

Ref

 DOACs

0.74 (0.52, 1.05)

0.93 (0.58, 1.48)

 Thrombolysis

0.49 (0.15, 1.55)

0.31 (0.09, 1.06)

 IVC filter

0.41 (0.17, 1.02)

0.27 (0.10, 0.75)

Hemorrhage, Yes vs. No

0.90 (0.44, 1.84)

KRS, High Risk vs. Median risk

1.39 (0.99, 1.96)

ECOG, ≥ 1 vs. 0

0.92 (0.65, 1.29)

CEA, High vs. Normal

1.55 (1.09, 2.20)

CA199, High vs. Normal

2.73 (1.91, 3.89)

2.05 (1.37, 3.06)

CA724, High vs. Normal

2.00 (1.39, 2.88)

Hemoglobin, Low vs. Normal

0.96 (0.55, 1.67)

Albumin, Low vs. Normal

1.06 (0.74, 1.51)

Platelet, Low vs. Normal

1.47 (1.02, 2.12)

1.78 (1.16, 2.73)

Platelet, High vs. Normal

1.41 (0.65, 3.05)

0.94 (0.36, 2.44)

Leucocyte, Low vs. Normal

1.11 (0.72, 1.71)

Leucocyte, High vs. Normal

1.17 (0.71, 1.92)

Neutrophil, Low vs. Normal

1.19 (0.78, 1.80)

Neutrophil, High vs. Normal

1.33 (0.85, 2.09)

Lymphocyte, Low vs. Normal

1.77 (1.26, 2.51)

0.97 (0.62, 1.50)

Lymphocyte, High vs. Normal

1.50 (0.60, 3.71)

3.08 (1.19, 7.97)

Fibrinogen, Low vs. Normal

0.80 (0.45, 1.43)

Fibrinogen, High vs. Normal

2.26 (1.31, 3.89)

D-dimer, High vs. Normal

1.43 (0.75, 2.75)

NLR, High vs. Normal

1.45 (1.03, 2.04)

PLR, High vs. Normal

1.97 (1.21, 3.20)

2.65 (1.37, 5.12)

F. nucleatum, Positive vs. Negative

1.92 (1.37, 2.70)

1.77 (1.17, 2.69)