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Table 3 Association between blood pressure measurements and coagulation factors. Results of the multivariable linear regressions in men and women

From: Sex-specific associations between systolic, diastolic and pulse pressure and hemostatic parameters in the population-based KORA-Fit study: a cross-sectional study

MEN

Systolic BP

 

Diastolic BP

 

Pulse pressure

 
 

ß-estimate (95% CI)

P-value

ß-estimate (95% CI)

P-value

ß-estimate (95% CI)

P-value

INR

0 (-0.001, 0)

0.497

0 (-0.001, 0.001)

0.942

0 (-0.001, 0)

0.394

aPTT (sec)

0.012 (-0.01, 0.034)

0.289

0 (-0.037, 0.038)

0.987

0.021 (-0.009, 0.051)

0.161

Protein C activity (%)

0.043 (-0.077, 0.163)

0.483

-0.041 (-0.243, 0.161)

0.69

0.108 (-0.054, 0.271)

0.192

Protein S activity (%)

-0.02 (-0.254, 0.214)

0.868

-0.047 (-0.438, 0.343)

0.812

-0.004 (-0.321, 0.313)

0.980

Antithrombin III (mg/dl)

0.012 (-0.058, 0.081)

0.739

0.01 (-0.107, 0.126)

0.868

0.014 (-0.08, 0.108)

0.768

Fibrinogen (mg/dl)

-0.185 (-0.592, 0.223)

0.374

-0.145 (-0.837, 0.548)

0.682

-0.255 (-0.805, 0.294)

0.362

D-dimers µg/l

-1.941 (-4.674, 0.793)

0.164

-0.501 (-5.108, 4.107)

0.831

-3.030 (-6.713, 0.653)

0.107

Factor VIII activity (%)

0.045 (-0.186, 0.277)

0.702

0.182 (-0.206, 0.569)

0.358

-0.038 (-0.349, 0.275)

0.816

WOMEN

Systolic BP

 

Diastolic BP

 

Pulse pressure

 
 

ß-estimate (95% CI)

P-value

ß-estimate (95% CI)

P-value

ß-estimate (95% CI)

P-value

INR

0.000 (0.000, 0.000)

0.896

0.000 (0.000, 0.001)

0.461

0.000 (-0.001, 0.000)

0.651

aPTT (sec)

-0.003 (-0.022, 0.016)

0.759

0.02 (-0.014, 0.054)

0.253

-0.02 (-0.049, 0.008)

0.164

Protein C activity (%)

0.065 (-0.042, 0.173)

0.233

0.127 (-0.063, 0.317)

0.19

0.055 (-0.103, 0.213)

0.492

Protein S activity (%)

0.024 (-0.154, 0.202)

0.795

-0.033 (-0.332, 0.267)

0.831

0.072 (-0.180, 0.324)

0.576

Antithrombin III (mg/dl)

-0.02 (-0.077, 0.038)

0.506

-0.044 (-0.143, 0.055)

0.385

-0.012 (-0.098, 0.075)

0.793

Fibrinogen (mg/dl)

-0.24 (-0.612, 0.132)

0.206

-0.341 (-1.004, 0.322)

0.313

-0.291 (-0.836, 0.255)

0.296

D-dimers (µg/l)

3.37 (0.935, 5.804)

0.007

2.718 (-1.614, 7.051)

0.218

5.351 (1.772, 8.930)

0.003

Factor VIII activity (%)

-0.029 (-0.235, 0.177)

0.785

-0.081 (-0.446, 0.283)

0.662

-0.004 (-0.307, 0.299)

0.978

  1. Exposures: systolic, diastolic, and pulse pressure; Outcomes: INR, aPTT, protein C, protein S, antithrombin III, fibrinogen, D-dimers, Factor VIII. Level of significance at P < 0.05. ß regression coefficient, CI Confidence interval, BP Blood pressure
  2. Adjusted for age, BMI, diabetes, smoking status, non HDL-Cholesterol, and medications acting on blood pressure. Participants with anticoagulative medication were excluded from the linear regression models
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Thrombosis Journal

ISSN: 1477-9560

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