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Table 2 Univariate analysis of portal vein thrombus resolution events

From: Development and external validation of prognostic scoring models for portal vein thrombosis: a multicenter retrospective study

Variable

Coefficient

Stat

HR (95%CI)

P value

Age

0.02

2.86

1.02(1.00,1.04)

0.0909

BMI

0.01

0.01

1.00(0.94,1.08)

0.9029

Drinking

-0.35

2.10

0.70(0.44,1.13)

0.1473

Smoking

-0.48

3.54

0.62(0.38,1.02)

0.0599

Liver disease

ā€ƒCirrhosis

-0.59

3.46

0.55(0.30,1.03)

0.0628

ā€ƒHepatic carcinoma

-0.32

0.81

0.73(0.37,1.45)

0.3684

Comorbidities

ā€ƒAtrial fibrillation

0.67

2.04

1.95(0.78,4.88)

0.1530

ā€ƒCoronary heart disease

0.41

1.29

1.50(0.75,3.02)

0.2562

ā€ƒCerebral infarction

0.22

0.40

1.24(0.64,2.41)

0.5257

ā€ƒDiabetes

-0.19

0.61

0.83(0.52,1.33)

0.4345

ā€ƒAscites

-0.41

3.31

0.67(0.43,1.03)

0.0687

ā€ƒSplenomegaly

-0.34

2.37

0.71(0.47,1.10)

0.1235

ā€ƒCurrent GIB

-0.13

0.26

0.88(0.54,1.44)

0.6126

ā€ƒHistory of GIB

-0.34

1.82

0.71(0.44,1.17)

0.1776

ā€ƒHistory of abdominal surgery

0.35

2.39

1.42(0.91,2.23)

0.1218

ā€ƒHistory of anticoagulants

0.63

3.59

1.87(0.98,3.57)

0.0580

ā€ƒHistory of blood transfusion

-0.11

0.21

0.90(0.56,1.44)

0.6501

ā€ƒHistory of anti-hypertensive drugs

-0.29

0.39

0.75(0.30,1.86)

0.5334

ā€ƒHistory of endoscopic operation

0.44

1.81

1.56(0.82,2.98)

0.1781

ā€ƒHistory of hepatic encephalopathy

-0.48

0.65

0.62(0.20,1.97)

0.4197

ā€ƒHistory of abdominal infection

-0.51

5.23

0.60(0.39,0.93)

0.0222

The site of thrombus involvement

ā€ƒMain portal vein thrombosis

-0.13

0.26

0.88(0.54,1.45)

0.6112

ā€ƒPortal branch thrombosis

-0.10

0.20

0.91(0.59,1.39)

0.6514

ā€ƒSMV thrombosis

-0.28

1.38

0.76(0.48,1.21)

0.2405

ā€ƒSplenic vein thrombosis

0.17

0.39

1.18(0.70,1.99)

0.5301

Esophageal varices

-0.44

3.38

0.64(0.40,1.03)

0.0660

ā€ƒRed color sign

-0.44

2.53

0.64(0.37,1.11)

0.1117

Degree of esophageal varices

ā€ƒmild

REF

Ā Ā Ā 

ā€ƒmoderate

0.20

0.20

1.22(0.51,2.94)

0.6526

ā€ƒsevere

0.23

0.29

1.26(0.55,2.88)

0.5896

CTP classification

ā€ƒLevel A

REF

Ā Ā Ā 

ā€ƒLevel B

-0.50

4.47

0.61(0.38,0.96)

0.0345

ā€ƒLevel C

-0.23

0.24

0.79(0.31,2.02)

0.6276

Laboratory findings

ā€ƒPTā€‰>ā€‰12.1(s)

-0.20

0.35

0.82(0.42,1.60)

0.5554

ā€ƒINRā€‰>ā€‰1.5

0.04

0.01

1.05(0.45,2.45)

0.9174

ā€ƒD-dimerā€‰>ā€‰0.55(mg/L)

0.03

0.01

1.03(0.41,2.56)

0.9490

ā€ƒWBC (Ɨā€‰109/L)

ā€ƒā€ƒ<ā€‰3.5

-0.19

0.54

0.83(0.51,1.36)

0.4616

ā€ƒā€ƒ>ā€‰9.5

-0.07

0.05

0.93(0.52,1.68)

0.8172

RBCā€‰ā‰„ā€‰3.8 (Ɨā€‰1012/L)

0.41

3.26

1.51(0.97,2.37)

0.0711

HBā€‰ā‰„ā€‰115(g/L)

0.49

4.68

1.64(1.05,2.56)

0.0306

PLTā€‰ā‰„ā€‰125 (Ɨā€‰109/L)

0.21

0.90

1.23(0.80,1.89)

0.3421

CRPā€‰>ā€‰5(mg/L)

-0.64

8.16

0.53(0.34,0.82)

0.0043

ALBā€‰ā‰„ā€‰40(g/L)

0.65

6.39

1.91(1.16,3.15)

0.0115

ALTā€‰>ā€‰40(U/L)

-0.25

0.71

0.78(0.44,1.39)

0.3983

ASTā€‰>ā€‰35(U/L)

0.41

3.40

1.51(0.97,2.34)

0.0652

TBILā€‰>ā€‰21(Ī¼mol/L)

0.13

0.35

1.14(0.74,1.77)

0.5528

DBILā€‰>ā€‰10.2(Ī¼mol/L)

-0.05

0.06

0.95(0.61,1.47)

0.8068

SCRā€‰>ā€‰92(Ī¼mol/L)

0.01

0.01

1.00(0.56,1.78)

0.9952

TGā€‰>ā€‰2.26(mmol/L)

-0.29

0.52

0.75(0.34,1.64)

0.4719

HDLā€‰ā‰„ā€‰1.15(mmol/L)

0.10

0.20

1.11(0.71,1.73)

0.6585

LDLā€‰>ā€‰2.16(mmol/L)

0.08

0.15

1.09(0.71,1.67)

0.7023

Kā€‰<ā€‰3.5(mmol/L)

0.14

0.27

1.15(0.67,1.98)

0.6043

AFPā€‰>ā€‰7(ng/mL)

0.23

0.62

1.26(0.71,2.22)

0.4307

Treatment and symptoms after diagnosis of PVT

ā€ƒHepatic encephalopathy

-0.64

2.84

0.53(0.25,1.11)

0.0919

ā€ƒEndoscope ligation

0.62

1.78

1.86(0.75,4.64)

0.1825

ā€ƒAbdominal infection

0.22

0.35

1.25(0.60,2.59)

0.5542

ā€ƒBlood transfusion

-0.26

1.01

0.77(0.46,1.29)

0.3161

ā€ƒAbdominal surgery

0.14

0.32

1.15(0.71,1.87)

0.5732

ā€ƒThrombolytic therapy

0.55

6.34

1.73(1.13,2.66)

0.0118

The drugs of thrombolytic therapy

ā€ƒno drugs

REF

Ā Ā Ā 

ā€ƒanticoagulants

0.80

11.00

2.22(1.39,3.55)

0.0009

ā€ƒantiplatelets

0.04

0.02

1.05(0.52,2.09)

0.9017

Anticoagulant drugs

ā€ƒlow molecular weight heparin

REF

Ā Ā Ā 

ā€ƒwarfarin

1.56

1.83

4.78(0.50,46.07)

0.1760

Anticoagulant duration

0.01

0.06

1.00(1.00,1.01)

0.8009

  1. HR Hazard ratio, CI Confidence interval, BMI Body mass index, GIB Gastrointestinal bleeding, SMV Superior mesenteric vein, PT Prothrombin time, INR International normalized ratio, WBC White blood cell, RBC Red blood cell, HB Hemoglobin, PLT Platelet count, CRP C-reactive protein, ALB Albumin, ALT Alanine aminotransferase, AST Aspartate aminotransferase, TBIL Total bilirubin, DBIL Direct bilirubin, SCR Serum creatinine, TG Triglyceride, HDL High-density lipoprotein, LDL Low-density lipoprotein, K Kalium, AFP Alpha-fetoprotein